Evidence map›Paper›PMID 33457406›Full record

ArticleBioMed research international2020

Curcumin and Glu-GNPs Induce Radiosensitivity against Breast Cancer Stem-Like Cells.

Ke Yang, Zhiwei Liao, Yujian Wu, Mengjie Li, Tingting Guo, Jiayi Lin, Yanwu Li, Chenxia Hu

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ke Yang *School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.ORCID https://orcid.org/0000-0001-5148-3370
Zhiwei Liao *Guangzhou Medical University Affiliated Cancer Hospital, Guangzhou 510635, China.ORCID https://orcid.org/0000-0003-0913-4091
Yujian WuSchool of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.ORCID https://orcid.org/0000-0002-5632-9636
Mengjie LiSchool of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.ORCID https://orcid.org/0000-0002-0619-8754
Tingting GuoSchool of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.ORCID https://orcid.org/0000-0002-9440-3243
Jiayi LinSchool of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.ORCID https://orcid.org/0000-0002-3099-8647
Yanwu LiScience and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.ORCID https://orcid.org/0000-0002-2562-7470
Chenxia HuSchool of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.ORCID https://orcid.org/0000-0001-9663-0776
Guangzhou University of Chinese Medicine · CNGuangzhou Medical University Cancer Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer stem cells are an important cause of radiotherapy resistance in the clinical treatment of breast cancer patients. How to target breast cancer stem cells is the key to improving the efficacy of breast cancer radiotherapy. We proposed for the first time that curcumin combined with glucose nanogold particles (Glu-GNPs) targeted breast cancer stem cells to reduce radiotherapy resistance, which can significantly enhance the apoptosis level of MCF-7 and MDA-MB-231 breast cancer stem-like cells (BCSCs) after radiotherapy and antiproliferation and colony-forming. Under simulated hypoxic conditions, curcumin combined with Glu-GNPs can significantly improve the ROS level of MCF-7 and MDA-MB-231 mammospheres; reduce the expression of HIF-1

Indexed as

ApoptosisBreast NeoplasmsCD24 AntigenCell AdhesionCell CycleCell Line, TumorCell SurvivalCurcuminFemaleGene Expression ProfilingGlucoseHumansHyaluronan ReceptorsHypoxiaMCF-7 CellsMetal NanoparticlesCD24 AntigenCD24 protein, humanCD44 protein, humanCurcuminGlucoseHyaluronan ReceptorsRadiation-Sensitizing AgentsReactive Oxygen Species

Identifiers

PMID33457406
PMCPMC7785366
OpenAlexW3117914113

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.