Evidence map›Paper›PMID 33457325›Full record

ArticleTranslational medicine @ UniSa2020

Drug-Induced Sleep Endoscopy (DISE) with Simulation Bite to Predict the Success of Oral Appliance Therapy in Treating Obstructive Sleep Apnea/Hypopnea Syndrome (OSAHS).

M Cavaliere, P De Luca, C De Santis, A Scarpa, M Ralli, A Di Stadio, P Viola, G Chiarella, C Cassandro, F Cassandro

Open access · hybridAbstract read
In one paragraph

Article in Translational medicine @ UniSa, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

M CavaliereOtolaryngology Department, University Hospital "San Giovanni di Dio e Ruggi D'Aragona", Salerno, Italy.
P De LucaDepartment of Medicine, Surgery and Dentistry, University of Salerno, Salerno, Italy.
C De SantisOtolaryngology Department, University Hospital "San Giovanni di Dio e Ruggi D'Aragona", Salerno, Italy.
A ScarpaDepartment of Medicine, Surgery and Dentistry, University of Salerno, Salerno, Italy.
M RalliDepartment of Sense Organs, Sapienza University of Rome, Rome, Italy.
A Di StadioDepartment of Otolaryngology, University of Perugia, Italy Department of Otolaryngology University of Perugia Italy.
P ViolaDepartment of Experimental and Clinical Medicine, Unit of Audiology and Phoniatrics, Magna Græcia University, Catanzaro, Italy.
G ChiarellaDepartment of Experimental and Clinical Medicine, Unit of Audiology and Phoniatrics, Magna Græcia University, Catanzaro, Italy.
C CassandroSurgical Sceinces Department, University of Turin, Turin, ITaly.
F CassandroDentistry Unit, Department of Neurosciences, University "Federico II", Napoli, Italy.
University of Salerno · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

objectivesOral appliances have gained their place in the treatment of obstructive sleep apnea (OSA) where custom-made titratable mandibular advancement devices (MAD) have become the oral appliance of choice. This study aimed to asses the value of the drug-induced sleep endoscopy (DISE) using a MAD in the prediction of treatment outcome for OSAHS.

methodsThis is a prospective, single-center cohort study that enrolled sixty-six consecutive patients with diagnosed OSA (5 events/h < apnea-hypopnea index (AHI) < 50 events/h) to be treated with a custom-made titratable MAD. The patients were evaluated polysomnographically with the MAD in situ after the adaptation and titration period of 3 months. The associations between findings during DISE and treatment outcome were assessed.

resultsThe subjects showed a wide range of severity of OSAHS pre-treatment: median AHI was 43.10 with a range from 20.13 to 66.07. The simulation bite was associated with a significant increase in cross-sectional area at level of the velopharynx, tongue base and epiglottis. MAD treatment response in the studied population was 91%, with a mean AHI improving from 43.10 to 12.93.

conclusionsDrug-induced sleep endoscopy with simulation bite is an acceptably reproducible technique for determining the sites of obstruction in OSAHS subjects; it thus offers possibilities as a prognostic indicator for treatment with MAD.

Indexed as

drug-induced sleep endoscopynasendoscopyobstructive sleep apneaoral appliancesimulation bite

Identifiers

PMID33457325
PMCPMC8370523
OpenAlexW3116632765

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.