Evidence map›Paper›PMID 33457189›Full record

ArticleCurrent sleep medicine reports2020

Association Between the Use of Non-benzodiazepine Hypnotics and Cognitive Outcomes: A Systematic Review.

Christopher N Kaufmann, Alison A Moore, Mark W Bondi, James D Murphy, Atul Malhotra, Laura A Hart

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current sleep medicine reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Christopher N KaufmannDivision of Geriatrics and Gerontology, Department of Medicine, University of California San Diego School of Medicine, La Jolla, CA.
Alison A MooreDivision of Geriatrics and Gerontology, Department of Medicine, University of California San Diego School of Medicine, La Jolla, CA.
Mark W BondiDepartment of Psychiatry, University of California San Diego School of Medicine, La Jolla, CA.
James D MurphyDepartment of Radiation Medicine and Applied Sciences, University of California San Diego School of Medicine, La Jolla, CA.
Atul MalhotraDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California San Diego School of Medicine, La Jolla, CA.
Laura A HartSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA.

Funding

UCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Mark W Bondi · 2019 to 2026
$34.9M
San Diego Resource Center for advancing Alzheimer's Research in Minority Seniors (ARMS)P30AG059299 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Tala Al-Rousan · 2018 to 2026
$7.4M
Re-visiting Methods for MCI Diagnosis to Improve Biomarker and Trial FindingsR01AG049810 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BONDI, MARK W, EDLAND, STEVEN DYAL · 2016 to 2020
$3.7M
Sedative-Hypnotic Use Patterns and Risk for Cognitive Decline and Alzheimer's DiseaseK01AG061239 · NIA · UNIVERSITY OF FLORIDA · PI KAUFMANN, CHRISTOPHER NORFLEET · 2019 to 2023
$656k
NIA NIH HHS K01 AG061239NIA NIH HHS P30 AG059299NIA NIH HHS P30 AG062429NIA NIH HHS R01 AG049810
6 · The paper itself

Abstract

purpose of reviewAdverse effects of sedative-hypnotic medications on cognition are concerning. Past studies have examined benzodiazepine (BZD) use and cognitive outcomes; however, few studies have examined newer non-BZD hypnotic agents (nBHs; e.g. zolpidem). This systematic review examined observational studies assessing the association between nBH use and cognitive outcomes. RECENT

findingsFive studies met eligibility requirements and were included in the review. Most studies did not find an association between nBH use and dementia diagnosis; however, we found no studies assessing other cognitive outcomes such as cognitive performance (e.g., word recall tasks). Characterization of nBH use mostly consisted of incident new use; one study assessed nBH dosing; none examined duration of use. Studies included were of strong quality. SUMMARY: This review found no association between nBH use and dementia diagnosis, although there is a need for more research on more cognitive outcomes and nBH use patterns.

Indexed as

Alzheimer’s diseasedementiainsomnianon-benzodiazepine hypnoticssleep medications

Identifiers

PMID33457189
PMCPMC7810183

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.