Evidence map›Paper›PMID 33457074›Full record

ArticleOncoimmunology2020

Expanded NK cells from umbilical cord blood and adult peripheral blood combined with daratumumab are effective against tumor cells from multiple myeloma patients.

Chantal Reina-Ortiz, Michael Constantinides, Alexis Fayd-Herbe-de-Maudave, Jessy Présumey, Javier Hernandez, Guillaume Cartron, David Giraldos, Rosana Díez, Isabel Izquierdo, Gemma Azaceta and 5 more

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 39 citations in OpenAlex.

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  7. Generation of non-genetically modified, CAR-like, NK cells.Journal for immunotherapy of cancer · 2024
    Article
  8. NK cells as powerful therapeutic tool in cancer immunotherapy.Cellular oncology (Dordrecht, Netherlands) · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Chantal Reina-OrtizApoptosis, Immunity & Cancer Group, Dept. Biochemistry and Molecular and Cell Biology, Faculty of Sciences, Campus San Francisco Sq., University of Zaragoza and Aragón Health Research Institute (IIS Aragón), Zaragoza, Spain.
Michael ConstantinidesCHU Montpellier, IRMB, Montpellier, France.
Alexis Fayd-Herbe-de-MaudaveCHU Montpellier, IRMB, Montpellier, France.
Jessy PrésumeyCHU Montpellier, IRMB, Montpellier, France.
Javier HernandezCHU Montpellier, IRMB, Montpellier, France.
Guillaume CartronDépartement d'Hématologie Clinique, CHU, Montpellier, France.
David GiraldosApoptosis, Immunity & Cancer Group, Dept. Biochemistry and Molecular and Cell Biology, Faculty of Sciences, Campus San Francisco Sq., University of Zaragoza and Aragón Health Research Institute (IIS Aragón), Zaragoza, Spain.
Rosana DíezHematology Department, Miguel Servet Hospital, Zaragoza, Spain.
Isabel IzquierdoHematology Department, Miguel Servet Hospital, Zaragoza, Spain.
Gemma AzacetaHematology Department, Lozano Blesa Hospital, Zaragoza, Spain.
Luis PalomeraHematology Department, Lozano Blesa Hospital, Zaragoza, Spain.
Isabel MarzoApoptosis, Immunity & Cancer Group, Dept. Biochemistry and Molecular and Cell Biology, Faculty of Sciences, Campus San Francisco Sq., University of Zaragoza and Aragón Health Research Institute (IIS Aragón), Zaragoza, Spain.
Javier NavalApoptosis, Immunity & Cancer Group, Dept. Biochemistry and Molecular and Cell Biology, Faculty of Sciences, Campus San Francisco Sq., University of Zaragoza and Aragón Health Research Institute (IIS Aragón), Zaragoza, Spain.
Alberto AnelApoptosis, Immunity & Cancer Group, Dept. Biochemistry and Molecular and Cell Biology, Faculty of Sciences, Campus San Francisco Sq., University of Zaragoza and Aragón Health Research Institute (IIS Aragón), Zaragoza, Spain.ORCID 0000-0002-5175-8394
Martín VillalbaCHU Montpellier, IRMB, Montpellier, France.ORCID 0000-0002-4385-4888
Universidad de Zaragoza · ESInstitute for Regenerative Medicine & Biotherapy · FRHospital Clínico Universitario Lozano Blesa · ESHospital Universitario Miguel Servet · ESCentre Hospitalier Universitaire de Montpellier · FRInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study we evaluated the potential of expanded NK cells (eNKs) from two sources combined with the mAbs daratumumab and pembrolizumab to target primary multiple myeloma (MM) cells

Indexed as

Multiple MyelomaAdultAntibodies, MonoclonalFetal BloodHumansKiller Cells, NaturalAntibodies, Monoclonaldaratumumabcell Therapy and ImmunotherapycytotoxicitydaratumumabMultiple MyelomaNK cellsPD-1

Identifiers

PMID33457074
PMCPMC7781838
OpenAlexW3116612664

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.