Evidence map›Paper›PMID 33456586›Full record

ArticleTheranostics2021

Machine learning identifies stroke features between species.

Salvador Castaneda-Vega, Prateek Katiyar, Francesca Russo, Kristin Patzwaldt, Luisa Schnabel, Sarah Mathes, Johann-Martin Hempel, Ursula Kohlhofer, Irene Gonzalez-Menendez, Leticia Quintanilla-Martinez and 6 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Cerebrovascular GMolecular imaging and biology · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Machine learning based analysis of stroke lesions on mouse tissue sections.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Article
  10. Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Salvador Castaneda-VegaWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen, Tuebingen, Germany.
Prateek KatiyarWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen, Tuebingen, Germany.
Francesca RussoDepartment of Neurology & Stroke, and Hertie Institute for Clinical Brain Research, Eberhard Karls University Tuebingen, Tuebingen, Germany.
Kristin PatzwaldtWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen, Tuebingen, Germany.
Luisa SchnabelDepartment of Nuclear Medicine and Clinical Molecular Imaging, Eberhard Karls University Tuebingen, Tuebingen, Germany.
Sarah MathesDepartment of Nuclear Medicine and Clinical Molecular Imaging, Eberhard Karls University Tuebingen, Tuebingen, Germany.
Johann-Martin HempelDepartment of Diagnostic and Interventional Neuroradiology, Eberhard Karls University Tuebingen, Tuebingen, Germany.
Ursula KohlhoferInstitute of Pathology and Neuropathology and Comprehensive Cancer Center Tübingen, Eberhard Karls University Tuebingen, Tübingen, Germany.
Irene Gonzalez-MenendezInstitute of Pathology and Neuropathology and Comprehensive Cancer Center Tübingen, Eberhard Karls University Tuebingen, Tübingen, Germany.
Leticia Quintanilla-MartinezInstitute of Pathology and Neuropathology and Comprehensive Cancer Center Tübingen, Eberhard Karls University Tuebingen, Tübingen, Germany.
Ulf ZiemannDepartment of Neurology & Stroke, and Hertie Institute for Clinical Brain Research, Eberhard Karls University Tuebingen, Tuebingen, Germany.
Christian la FougereDepartment of Nuclear Medicine and Clinical Molecular Imaging, Eberhard Karls University Tuebingen, Tuebingen, Germany.
Ulrike ErnemannDepartment of Diagnostic and Interventional Neuroradiology, Eberhard Karls University Tuebingen, Tuebingen, Germany.
Bernd J PichlerWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen, Tuebingen, Germany.
Jonathan A DisselhorstWerner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen, Tuebingen, Germany.
Sven PoliDepartment of Neurology & Stroke, and Hertie Institute for Clinical Brain Research, Eberhard Karls University Tuebingen, Tuebingen, Germany.
Siemens (Germany) · DEUniversity of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Identification and localization of ischemic stroke (IS) lesions is routinely performed to confirm diagnosis, assess stroke severity, predict disability and plan rehabilitation strategies using magnetic resonance imaging (MRI). In basic research, stroke lesion segmentation is necessary to study complex peri-infarction tissue changes. Moreover, final stroke volume is a critical outcome evaluated in clinical and preclinical experiments to determine therapy or intervention success. Manual segmentations are performed but they require a specialized skill set, are prone to inter-observer variation, are not entirely objective and are often not supported by histology. The task is even more challenging when dealing with large multi-center datasets, multiple experimenters or large animal cohorts. On the other hand, current automatized segmentation approaches often lack histological validation, are not entirely user independent, are often based on single parameters, or in the case of complex machine learning methods, require vast training datasets and are prone to a lack of model interpretation.

Indexed as

AlgorithmsAnimalsBrainBrain IschemiaDiffusion Magnetic Resonance ImagingDisease Models, AnimalHumansImage Processing, Computer-AssistedInfarction, Middle Cerebral ArteryMachine LearningMaleRatsRats, Sprague-DawleyStrokeIschemic strokeMachine learningStroke segmentation NeuroimagingTranslational medicine

Identifiers

PMID33456586
PMCPMC7806470
OpenAlexW3120608793

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.