Evidence map›Paper›PMID 33456518›Full record

ArticleExperimental and therapeutic medicine2021

Inhibitory effect of isomorellin on cholangiocarcinoma cells via suppression of NF-κB translocation, the phosphorylated p38 MAPK pathway and MMP-2 and uPA expression.

Chariya Hahnvajanawong, Thitiporn Sahakulboonyarak, Thidarut Boonmars, Vichai Reutrakul, Anusak Kerdsin, Parichart Boueroy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental and therapeutic medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Caged Polyprenylated Xanthones inDrug design, development and therapy · 2023
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chariya HahnvajanawongDepartment of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Thitiporn SahakulboonyarakDepartment of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Thidarut BoonmarsCholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen 40002, Thailand.
Vichai ReutrakulDepartment of Chemistry, Faculty of Science, Center of Excellence for Innovation in Chemistry, Mahidol University, Bangkok 10400, Thailand.
Anusak KerdsinFaculty of Public Health, Kasetsart University Chalermphrakiat Sakon Nakhon Province Campus, Sakon Nakhon 47000, Thailand.
Parichart BoueroyFaculty of Public Health, Kasetsart University Chalermphrakiat Sakon Nakhon Province Campus, Sakon Nakhon 47000, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evidence indicates that most cancer deaths are caused by tumor invasion and metastasis. Cholangiocarcinoma (CCA) is a tumor of the bile duct epithelium characterized by slow growth, rapid metastasis and poor prognosis. Caged xanthones are extracted from gamboge, a dry resin exuded by

Indexed as

anti-metastasischolangiocarcinomaisomorellinMAPK pathwayNF-κB

Identifiers

PMID33456518
PMCPMC7792505

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.