Evidence map›Paper›PMID 33456458›Full record

ReviewGastroenterology research and practice2020

The Role of Active Inflammation and Surgical Therapy in Crohn's Disease Recurrence.

S Ingallinella, M Campanelli, A Antonelli, C Arcudi, V Bellato, A Divizia, M Franceschilli, L Petagna, B Sensi, S Sibio and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Gastroenterology research and practice, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Intriguing Role of the Mesentery in Ileocolic Crohn's Disease.Clinics in colon and rectal surgery · 2022
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

S IngallinellaDepartment of Surgery, Tor Vergata University of Rome, Viale Oxford 81, 00133 Rome, Italy.ORCID https://orcid.org/0000-0002-5600-2799
M CampanelliDepartment of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia (UNIMO), Modena, Italy.ORCID https://orcid.org/0000-0002-2134-2275
A AntonelliDepartment of Surgery, Tor Vergata University of Rome, Viale Oxford 81, 00133 Rome, Italy.ORCID https://orcid.org/0000-0002-5773-6962
C ArcudiDepartment of Surgery, Tor Vergata University of Rome, Viale Oxford 81, 00133 Rome, Italy.
V BellatoDepartment of Surgery, Tor Vergata University of Rome, Viale Oxford 81, 00133 Rome, Italy.
A DiviziaDepartment of Surgery, Tor Vergata University of Rome, Viale Oxford 81, 00133 Rome, Italy.
M FranceschilliObesity Unit, Department of Surgery, University of Rome "Tor Vergata", Rome, Italy.ORCID https://orcid.org/0000-0002-2516-4621
L PetagnaObesity Unit, Department of Surgery, University of Rome "Tor Vergata", Rome, Italy.
B SensiDepartment of Surgery, Tor Vergata University of Rome, Viale Oxford 81, 00133 Rome, Italy.ORCID https://orcid.org/0000-0003-1912-2414
S SibioDepartment of Surgery "Pietro Valdoni", Sapienza University of Rome, Via Lancisi 2, 00155 Rome, Italy.
L SiragusaDepartment of Surgery, Tor Vergata University of Rome, Viale Oxford 81, 00133 Rome, Italy.ORCID https://orcid.org/0000-0001-9218-1176
G S SicaObesity Unit, Department of Surgery, University of Rome "Tor Vergata", Rome, Italy.ORCID https://orcid.org/0000-0002-7407-0584

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An altered balance between effector and regulatory factors is supposed to sustain the tissue-damaging immune response in inflammatory bowel disease (IBD). Several studies demonstrate that severe active inflammation is a strong predictor for surgical complications and recurrence. Indeed, bowel resection in Crohn's disease (CD) patients has a high surgical recurrence rate. In this review, we examined the IBD inflammatory pathways, the current surgical treatments, and the almost inevitable recurrence. The question that might arise is if the cure of intestinal CD is to be found in the surgical approach. A selective search of two databases (PubMed and the Cochrane Library) has been carried out without considering a specific time horizon as inclusion criteria. The scope of this literature review was investigating on the role of inflammation in the management of CD. The following key words have been used to develop the query string: (

Identifiers

PMID33456458
PMCPMC7785378

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.