Evidence map›Paper›PMID 33456291›Full record

ArticleMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents2021

Synthesis of 4-oxotetrahydropyrimidine-1(2H)-carboxamides derivatives as capsid assembly modulators of hepatitis B virus.

Nicky Hwang, Haiqun Ban, Junjun Chen, Julia Ma, Hui Liu, Patrick Lam, John Kulp, Stephan Menne, Jinhong Chang, Ju-Tao Guo and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Nicky Hwang *Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, PA 18902 USA.
Haiqun Ban *Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, PA 18902 USA.
Junjun ChenBaruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, PA 18902 USA.
Julia MaBaruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, PA 18902 USA.
Hui LiuBaruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, PA 18902 USA.
Patrick LamBaruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, PA 18902 USA.
John KulpBaruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, PA 18902 USA.
Stephan MenneGeorgetown University Medical Center, 3900 Reservoir Road, Washington, DC 20057 USA.
Jinhong ChangBaruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, PA 18902 USA.
Ju-Tao GuoBaruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, PA 18902 USA.
Yanming DuBaruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, PA 18902 USA.ORCID 0000-0002-4665-8348
Baruch S. Blumberg Institute · USGeorgetown University · USPeking University · CNRenji Hospital · CN

Funding

Evaulation of therapeutic benefits of HBV nucleocapsid assembly inhibitorsR01AI113267 · NIAID · DREXEL UNIVERSITY · PI DU, YANMING, GUO, JU-TAO · 2014 to 2018
$2.9M
NIAID NIH HHS R01 AI113267
6 · The paper itself

Abstract

We report herein the synthesis and evaluation of phenyl ureas derived from 4-oxotetrahydropyrimidine as novel capsid assembly modulators of hepatitis B virus (HBV). Among the derivatives, compound

Indexed as

4-OxotetrahydropyrimidineCapsid assemblyHepatitis B virusPhenyl ureas

Identifiers

PMID33456291
PMCPMC7797712
OpenAlexW3120535864

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.