Evidence map›Paper›PMID 33456108›Full record

Trial reportActa clinica Croatica2020

The effect of atorvastatin on the common carotid artery intima-media thickness in patients with ischemic stroke.

Mojtaba Khazaei, Mozhdeh Khosravi, Shahir Mazaheri, Mehrdokht Mazdeh, Masoud Ghiasian, Mohammad Taheri, Soudeh Ghafouri-Fard

Open access · diamondAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Acta clinica Croatica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. The possible modulatory impact of high-dose statin therapy on carotid intima-media thickness: a preliminary study.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2024
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Mojtaba Khazaei1Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran; 2Department of Neurology, Hamadan University of Medical Sciences, Hamadan, Iran; 3Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 4Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mozhdeh Khosravi1Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran; 2Department of Neurology, Hamadan University of Medical Sciences, Hamadan, Iran; 3Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 4Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Shahir Mazaheri1Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran; 2Department of Neurology, Hamadan University of Medical Sciences, Hamadan, Iran; 3Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 4Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mehrdokht Mazdeh1Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran; 2Department of Neurology, Hamadan University of Medical Sciences, Hamadan, Iran; 3Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 4Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Masoud Ghiasian1Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran; 2Department of Neurology, Hamadan University of Medical Sciences, Hamadan, Iran; 3Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 4Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohammad Taheri1Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran; 2Department of Neurology, Hamadan University of Medical Sciences, Hamadan, Iran; 3Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 4Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Soudeh Ghafouri-Fard1Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran; 2Department of Neurology, Hamadan University of Medical Sciences, Hamadan, Iran; 3Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 4Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Hamedan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Occlusion of the initial segment of internal carotid artery is the most common reason for vascular events in the brain. The purpose of this study was to investigate the effect of one-year treatment with atorvastatin on intima-media thickness (IMT) of carotid arteries as a measure of atherosclerosis in stroke patients. In this prospective interventional study, 44 patients with ischemic stroke were investigated. Patients were treated with atorvastatin 40 mg once a day for one year. IMT of carotid arteries was measured by extracranial Doppler ultrasonography in the distal part of the common carotid artery at the beginning of the study, at 6 months and one year of treatment with atorvastatin. The IMT of both right and left carotid arteries decreased after 6- and 12-month atorvastatin treatment. Based on the results of this study, long-term administration of atorvastatin was associated with reduction in carotid artery IMT in patients with ischemic stroke. Such a decrease in IMT may prevent subsequent stroke or cardiovascular events in these patients.

Indexed as

AtorvastatinBrain IschemiaCarotid Intima-Media ThicknessHydroxymethylglutaryl-CoA Reductase InhibitorsIschemic StrokeStrokeCarotid ArteriesCarotid Artery, CommonHumansProspective StudiesRisk FactorsAtorvastatinHydroxymethylglutaryl-CoA Reductase InhibitorsAtorvastatinCommon carotid arteryIntima-media thicknessStroke

Identifiers

PMID33456108
PMCPMC7808223
OpenAlexW3092473573

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.