ArticleMacromolecules2021
FRET-Based Determination of the Exchange Dynamics of Complex Coacervate Core Micelles.
Article in Macromolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 36 citations in OpenAlex.
- Advances in FRET-based Applications Within Biomimicking Molecular Self-assemblies.Journal of fluorescence · 2026Review
- Compositional memory matters for early molecular systems.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Unimer Exchange as a Tool for Programming Enzymatic Degradation through Micellar Dynamics.Biomacromolecules · 2025Article
- Coacervation in Slow Motion: Kinetics of Complex Micelle Formation Induced by the Hydrolysis of an Antibiotic Prodrug.Molecular pharmaceutics · 2024Article
- Crafting Stable Antibiotic Nanoparticles via Complex Coacervation of Colistin with Block Copolymers.Biomacromolecules · 2024Article
- Fluorescence-readout as a powerful macromolecular characterisation tool.Chemical science · 2023Review
- Effect of Charged Block Length Mismatch on Double Diblock Polyelectrolyte Complex Micelle Cores.Macromolecules · 2023Article
- Article
- DNA dynamics in complex coacervate droplets and micelles.Soft matter · 2022Article
- Universal Scaling for the Exit Dynamics of Block Copolymers from Micelles at Short and Long Time Scales.Macromolecules · 2022Article
- Responsive Pickering Emulsions Stabilized by Frozen Complex Coacervate Core Micelles.ACS macro letters · 2022Article
- Advances in the Structural Design of Polyelectrolyte Complex Micelles.The journal of physical chemistry. B · 2021Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Complex coacervate core micelles (C3Ms) are nanoscopic structures formed by charge interactions between oppositely charged macroions and used to encapsulate a wide variety of charged (bio)molecules. In most cases, C3Ms are in a dynamic equilibrium with their surroundings. Understanding the dynamics of molecular exchange reactions is essential as this determines the rate at which their cargo is exposed to the environment. Here, we study the molecular exchange in C3Ms by making use of Förster resonance energy transfer (FRET) and derive an analytical model to relate the experimentally observed increase in FRET efficiency to the underlying macromolecular exchange rates. We show that equilibrated C3Ms have a broad distribution of exchange rates. The overall exchange rate can be strongly increased by increasing the salt concentration. In contrast, changing the unlabeled homopolymer length does not affect the exchange of the labeled homopolymers and an increase in the micelle concentration only affects the FRET increase rate at low micelle concentrations. Together, these results suggest that the exchange of these equilibrated C3Ms occurs mainly by expulsion and insertion, where the rate-limiting step is the breaking of ionic bonds to expel the chains from the core. These are important insights to further improve the encapsulation efficiency of C3Ms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.