Evidence map›Paper›PMID 33456051›Full record

ArticleMolecular psychiatry2021

Natural killer cells in first-episode psychosis: an innate immune signature?

Nadine Tarantino, Marion Leboyer, Arthur Bouleau, Nora Hamdani, Jean Romain Richard, Wahid Boukouaci, Wu Ching-Lien, Ophelia Godin, Djaouida Bengoufa, Philippe Le Corvoisier and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

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  16. Natural Killer T-like Cells: Immunobiology and Role in Disease.International journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Nadine Tarantino *Sorbonne Université, Inserm U1135, CNRS ERL 8255, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), F-75013, Paris, France.
Marion Leboyer *Université Paris Est Créteil, INSERM U955, IMRB, Laboratoire Neuro-Psychiatrie translationnelle, F-94010, Créteil, France.
Arthur BouleauUniversité Paris Est Créteil, INSERM U955, IMRB, Laboratoire Neuro-Psychiatrie translationnelle, F-94010, Créteil, France.
Nora HamdaniAP-HP, Hôpital Henri Mondor, Département Médico-Universitaire de Psychiatrie et d'Addictologie (DMU IMPACT), Fédération Hospitalo-Universitaire de Médecine de Précision (FHU ADAPT), F-94010, Créteil, France.
Jean Romain RichardUniversité Paris Est Créteil, INSERM U955, IMRB, Laboratoire Neuro-Psychiatrie translationnelle, F-94010, Créteil, France.
Wahid BoukouaciUniversité Paris Est Créteil, INSERM U955, IMRB, Laboratoire Neuro-Psychiatrie translationnelle, F-94010, Créteil, France.
Wu Ching-LienUniversité Paris Est Créteil, INSERM U955, IMRB, Laboratoire Neuro-Psychiatrie translationnelle, F-94010, Créteil, France.ORCID http://orcid.org/0000-0002-3254-6433
Ophelia GodinUniversité Paris Est Créteil, INSERM U955, IMRB, Laboratoire Neuro-Psychiatrie translationnelle, F-94010, Créteil, France.
Djaouida BengoufaFondation FondaMental, F-94010, Créteil, France.
Philippe Le CorvoisierUniversité Paris Est Créteil, Centre Investigation Clinique, CIC Henri Mondor, Créteil, F94010, France.
Caroline BarauPlateforme de Ressources Biologiques, HU Henri Mondor, F94010, Créteil, France.
Katia LedudalUniversité Paris Est Créteil, Centre Investigation Clinique, CIC Henri Mondor, Créteil, F94010, France.
Patrice DebréSorbonne Université, Inserm U1135, CNRS ERL 8255, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), F-75013, Paris, France.
Ryad TamouzaUniversité Paris Est Créteil, INSERM U955, IMRB, Laboratoire Neuro-Psychiatrie translationnelle, F-94010, Créteil, France.ORCID http://orcid.org/0000-0003-3992-9565
Vincent VieillardSorbonne Université, Inserm U1135, CNRS ERL 8255, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), F-75013, Paris, France. vincent.vieillard@sorbonne-universite.fr.ORCID http://orcid.org/0000-0002-9362-3922
Inserm · FRCentre National de la Recherche Scientifique · FRUniversité Paris-Est Créteil · FRAssistance Publique – Hôpitaux de Paris · FRFondation FondaMental · FRHôpitaux Universitaires Henri-Mondor · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accumulating evidence majorly implicates immune dysfunction in the etiology of psychotic disorders. In particular, altered numbers and functions of natural killer (NK) cells have been described in psychosis, but interpretation has often been confounded by a number of biases, including treatment. Eighty-one first-episode psychosis (FEP) patients who subsequently received a diagnosis of either schizophrenia (SZ; n = 30) or bipolar disorder (BP; n = 31) over a five-year follow-up period were investigated for their NK cell phenotype and compared to 61 healthy controls (HCs). We found a similar proportion of CD3

Indexed as

Bipolar DisorderPsychotic DisordersSchizophreniaHumansImmunity, InnateKiller Cells, Natural

Identifiers

PMID33456051
OpenAlexW3125096610

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.