ArticleThe Journal of veterinary medical science2021
Platelet abnormalities and platelet-to-lymphocyte ratios in canine immunosuppressant-responsive and non-responsive enteropathy: A retrospective study in 41 dogs.
Article in The Journal of veterinary medical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- ACVIM-endorsed statement: consensus statement and systematic review on guidelines for the diagnosis and treatment of chronic inflammatory enteropathy in dogs.Journal of veterinary internal medicine · 2026Pooled it
- Rethinking clinical response criteria in trials of chronic enteropathy in dogs: what change is truly meaningful?Journal of veterinary internal medicine · 2026Article
- Diagnostic Value of Correlation Between Canine Chronic Enteropathy Clinical Activity Index (CCECAI) and Selected Hematological and Immunological Biomarkers in Dogs with Chronic Enteropathy: A Systematic Meta-Analysis.Veterinary sciences · 2026Article
- Evaluation of Hemogram-Derived Inflammatory Markers in Healthy Cats.Veterinary sciences · 2026Article
- Reference Intervals for Hematological Inflammatory Ratios in Healthy Dogs.Animals : an open access journal from MDPI · 2025Article
- Feline Peritoneal Effusions-A Poor Prognosis?Animals : an open access journal from MDPI · 2025Article
- Blood Leukocyte Ratios as Predictive Markers of Chronic Enteropathy Phenotypes in Cats.Veterinary sciences · 2025Article
- Hematological Markers to Predict Enterectomy Versus Enterotomy in Dogs with Foreign-Body Intestinal Obstruction: Preliminary Data.Animals : an open access journal from MDPI · 2024Article
- A retrospective study of the aetiology of increased mean platelet volume in dogs presented to a small animal teaching hospital in Greece.Veterinary record open · 2024Article
- Diagnostic benefits of platelet-to-lymphocyte, neutrophil-to-lymphocyte, and albumin-to-globulin ratios in dogs with nasal cavity diseases.BMC veterinary research · 2024Article
- Prognostic Efficacy of Complete Blood Count Indices for Assessing the Presence and the Progression of Myxomatous Mitral Valve Disease in Dogs.Animals : an open access journal from MDPI · 2023Article
- Complete Blood Count-Derived Inflammatory Markers Changes in Dogs with Chronic Inflammatory Enteropathy Treated with Adipose-Derived Mesenchymal Stem Cells.Animals : an open access journal from MDPI · 2022Article
- Expression of genes encoding inflammasome sensor subunits in the duodenal and colonic mucosae of dogs with chronic enteropathy.The Journal of veterinary medical science · 2021Article
- Retrospective evaluation of hematological ratios in canine parvovirosis: 401 cases.Journal of veterinary internal medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Few studies have examined platelet alterations in dogs with chronic enteropathy. Our aim was to investigate platelet count (PLT), mean platelet volume (MPV), and platelet-to-lymphocyte ratio (PLR) in dogs diagnosed with immunosuppressant-responsive enteropathy (IRE). In this retrospective study of 41 dogs, data regarding signalment, canine chronic enteropathy clinical activity index (CCECAI), endoscopic and histopathological scores, PLT, MPV, PLR, total serum protein concentrations, albumin, and iron were collected. Clinical response and relapse were assessed with the evaluation of CCECAI over time. One month after starting therapy, dogs with >25% CCECAI reduction were considered responders. During a three-month CCECAI evaluation as part of a twelve-month follow-up, a CCECAI >3 together with a ≥2 unit increase in responder dogs was considered a relapse. PLT and PLR displayed significant negative correlation with MPV. MPV was positively correlated with total protein and albumin levels and negatively correlated with CCECAI. Three dogs were classified as non-responders, and 14 relapsed within 12 months. No differences were observed in PLT, MPV, or PLR between responding/non-responding and relapsing/non-relapsing groups. PLT, MPV, and PLR correlated with total protein, albumin, and CCECAI, confirming PLT as a potential marker, and suggesting MPV as a new marker of clinical efficacy against canine IRE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.