Evidence map›Paper›PMID 33455933›Full record

Observational studyBMJ open2021

Probability of receiving a high cumulative radiation dose and primary clinical indication of CT examinations: a 5-year observational cohort study.

Cécile R L P N Jeukens, Hub Boere, Bart A J M Wagemans, Patty J Nelemans, Estelle C Nijssen, Rebecca Smith-Bindman, Joachim E Wildberger, Anna M Sailer

Abstract readObservational Study
In one paragraph

Observational study in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. CT scanning and questions about benefit versus risk.Journal of applied clinical medical physics · 2025
    Article
  3. Article
  4. Article
  5. Radiation risk issues in recurrent imaging.The British journal of radiology · 2021
    Review
  6. The cumulative radiation dose paradigm in pediatric imaging.The British journal of radiology · 2021
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cécile R L P N JeukensDepartment of Radiology and Nuclear Medicine, Maastricht University Medical Centre+, Maastricht, The Netherlands cecile.jeukens@mumc.nl.ORCID 0000-0003-1403-8301
Hub BoereDepartment of Radiology and Nuclear Medicine, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Bart A J M WagemansDepartment of Radiology and Nuclear Medicine, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Patty J NelemansDepartment of Epidemiology, Maastricht University, Maastricht, The Netherlands.
Estelle C NijssenDepartment of Radiology and Nuclear Medicine, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Rebecca Smith-BindmanDepartment of Radiology and Biomedical Imaging Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA.
Joachim E WildbergerDepartment of Radiology and Nuclear Medicine, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Anna M SailerDepartment of Radiology and Nuclear Medicine, Maastricht University Medical Centre+, Maastricht, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveHigh radiation exposure is a concern because of the association with cancer. The objective was to determine the probability of receiving a high radiation dose from CT (from one or more examinations within a 5-year period) and to assess the clinical context by evaluating clinical indications in the high-dose patient group.

designObservational cohort study. Effective radiation dose received from one or more CT examinations within a predefined 5-year calendar period was assessed for each patient.

settingHospital setting.

participantsAll patients undergoing a diagnostic CT examination between July 2013 and July 2018 at the Maastricht University Medical Center. PRIMARY AND SECONDARY OUTCOME MEASURES: The primary outcome was the probability of receiving a high effective dose, defined as ≥100 mSv, from one or more CT examinations within 5 years as derived from a time-to-event analysis. Secondary outcomes were the clinical indication for the initial scan of patients receiving a high effective dose.

results100 672 CT examinations were performed among 49 978 patients including 482 (1%) who received a high radiation dose. The estimated probability of a high effective dose from a single examination is low (0.002% (95% CI 0.00% to 0.01%)). The 4.5-year probability of receiving a high cumulative effective dose was 1.9% (95% CI 1.6% to 2.2%) for women and 1.5% (95% CI 1.3% to 1.7%) for men. The probability was highest in age categories between 51 and 74 years. A total of 2711 (5.5%) of patients underwent more than six CT examinations, and the probability of receiving a high effective dose was 16%. Among patients who received a high effective dose, most indications (80%) were oncology related.

conclusionsThe probability of receiving a high radiation dose from CT examinations is small but not negligible. In the majority (80%) of high effective dose receiving patients, the indication for the initial CT scan was oncology related.

Indexed as

Radiation ExposureTomography, X-Ray ComputedAgedCohort StudiesFemaleHumansMaleMiddle AgedProbabilityRadiation Dosagecomputed tomographyhealth policyradiation oncology

Identifiers

PMID33455933
PMCPMC7813417

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.