Evidence map›Paper›PMID 33455913›Full record

ArticleBMJ health & care informatics2021

Artificial intelligence-based prediction of transfusion in the intensive care unit in patients with gastrointestinal bleeding.

Riccardo Levi, Francesco Carli, Aldo Robles Arévalo, Yuksel Altinel, Daniel J Stein, Matteo Maria Naldini, Federica Grassi, Andrea Zanoni, Stan Finkelstein, Susana M Vieira and 3 more

Abstract read
In one paragraph

Article in BMJ health & care informatics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  7. [Emerging Diagnostic Techniques and Therapies for Upper Gastrointestinal Bleeding].The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Riccardo LeviDepartment of Electronic, Information and Bioengineering, Politecnico di Milano, Milano, Italy riccardo.levi@mail.polimi.it.ORCID http://orcid.org/0000-0001-9030-0071
Francesco CarliDepartment of Informatics, Università degli Studi di Torino, Torino, Piemonte, Italy.
Aldo Robles ArévaloIDMEC, Instituto Superior Tecnico, Universidade de Lisboa, Lisbon, Portugal.
Yuksel AltinelGeneral Surgery Department, Istanbul Bagcilar Training and Research Hospital, Istanbul, Turkey.
Daniel J SteinDepartment of Internal Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Matteo Maria NaldiniSan Raffaele Telethon Institute for Gene Therapy, Milano, Lombardia, Italy.
Federica GrassiSchool of Medicine and Surgery, Università degli Studi di Milano-Bicocca, Milano, Lombardia, Italy.
Andrea ZanoniInstitute of Mathematics, Ecole Polytechnique Federale de Lausanne, Lausanne, VD, Switzerland.
Stan FinkelsteinInstitute for Data, Systems, and Society, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Susana M VieiraIDMEC, Instituto Superior Tecnico, Universidade de Lisboa, Lisbon, Portugal.
João SousaIDMEC, Instituto Superior Tecnico, Universidade de Lisboa, Lisbon, Portugal.
Riccardo BarbieriDepartment of Electronic, Information and Bioengineering, Politecnico di Milano, Milano, Italy.
Leo Anthony CeliLaboratory for Computational Physiology, Harvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts, USA.ORCID http://orcid.org/0000-0001-6712-6626

Funding

Critical Care Informatics: Ethical considerations around the use and sharing of health-related dataR01EB017205 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI CELI, LEO ANTHONY G, MARK, ROGER GREENWOOD · 2014 to 2021
$3.8M
NIBIB NIH HHS R01 EB017205
6 · The paper itself

Abstract

objectiveGastrointestinal (GI) bleeding commonly requires intensive care unit (ICU) in cases of potentialhaemodynamiccompromise or likely urgent intervention. However, manypatientsadmitted to the ICU stop bleeding and do not require further intervention, including blood transfusion. The present work proposes an artificial intelligence (AI) solution for the prediction of rebleeding in patients with GI bleeding admitted to ICU.

methodsA machine learning algorithm was trained and tested using two publicly available ICU databases, the Medical Information Mart for Intensive Care V.1.4 database and eICU Collaborative Research Database using freedom from transfusion as a proxy for patients who potentially did not require ICU-level care. Multiple initial observation time frames were explored using readily available data including labs, demographics and clinical parameters for a total of 20 covariates.

resultsThe optimal model used a 5-hour observation period to achieve an area under the curve of the receiving operating curve (ROC-AUC) of greater than 0.80. The model was robust when tested against both ICU databases with a similar ROC-AUC for all.

conclusionsThe potential disruptive impact of AI in healthcare innovation is acknowledge, but awareness of AI-related risk on healthcare applications and current limitations should be considered before implementation and deployment. The proposed algorithm is not meant to replace but to inform clinical decision making. Prospective clinical trial validation as a triage tool is warranted.

Indexed as

Artificial IntelligenceBlood TransfusionGastrointestinal HemorrhageIntensive Care UnitsFemaleHumansMaleProspective StudiesROC CurveBMJ health informaticscomputer methodologies

Identifiers

PMID33455913
PMCPMC7813389

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.