Evidence map›Paper›PMID 33455856›Full record

ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2021

Brainstem Pathologies Correlate With Depression and Psychosis in Parkinson's Disease.

Nicole Mercado Fischer, Jared T Hinkle, Kate Perepezko, Catherine C Bakker, Meaghan Morris, Martinus P G Broen, Ankur Butala, Ted M Dawson, Albert F G Leentjens, Zoltan Mari and 10 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

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  7. Depression in dementia with Lewy bodies: a critical update.Journal of neural transmission (Vienna, Austria : 1996) · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 2 countries.

Nicole Mercado FischerDepartment of Psychiatry and Behavioral Sciences (NMF, JTH, KP, MDS, AB, GMP), Johns Hopkins School of Medicine, Baltimore, MD.
Jared T HinkleDepartment of Psychiatry and Behavioral Sciences (NMF, JTH, KP, MDS, AB, GMP), Johns Hopkins School of Medicine, Baltimore, MD; Medical Scientist Training Program (JTH), Johns Hopkins School of Medicine, Baltimore, MD.
Kate PerepezkoDepartment of Psychiatry and Behavioral Sciences (NMF, JTH, KP, MDS, AB, GMP), Johns Hopkins School of Medicine, Baltimore, MD.
Catherine C BakkerMorris K. Udall Parkinson's Disease Research Center of Excellence (CCB, ZM, KAM, LSR, AP, JCT, GMP), Johns Hopkins School of Medicine, Baltimore, MD.
Meaghan MorrisClinical and Neuropathology Core (MM, OP, JCT), Johns Hopkins School of Medicine, Baltimore, MD.
Martinus P G BroenDepartment of Neurology (MPGB), Maastricht University Medical Centre, Maastricht, the Netherlands.
Ankur ButalaDepartment of Neurology (AB, TMD, CLM, KAM, LSR, AP, GMP), Johns Hopkins School of Medicine, Baltimore MD.
Ted M DawsonDepartment of Neurology (AB, TMD, CLM, KAM, LSR, AP, GMP), Johns Hopkins School of Medicine, Baltimore MD; Neuroregeneration and Stem Cell Programs (TMD), Institute for Cell Engineering, Johns Hopkins School of Medicine, Baltimore, MD; Solomon H. Snyder Department of Neuroscience (TMD), Johns Hopkins School of Medicine, Baltimore, MD; Department of Pharmacology and Molecular Sciences (TMD), Johns Hopkins School of Medicine, Baltimore, MD.
Albert F G LeentjensDepartment of Psychiatry (AFGL), Maastricht University Medical Centre, Maastricht, The Netherlands.
Zoltan MariMorris K. Udall Parkinson's Disease Research Center of Excellence (CCB, ZM, KAM, LSR, AP, JCT, GMP), Johns Hopkins School of Medicine, Baltimore, MD; Lou Ruvo Center for Brain Health (ZM), Cleveland Clinic, Las Vegas, NV.
Cherie L MarvelDepartment of Neurology (AB, TMD, CLM, KAM, LSR, AP, GMP), Johns Hopkins School of Medicine, Baltimore MD.
Kelly A MillsMorris K. Udall Parkinson's Disease Research Center of Excellence (CCB, ZM, KAM, LSR, AP, JCT, GMP), Johns Hopkins School of Medicine, Baltimore, MD; Department of Neurology (AB, TMD, CLM, KAM, LSR, AP, GMP), Johns Hopkins School of Medicine, Baltimore MD.
Liana S RosenthalMorris K. Udall Parkinson's Disease Research Center of Excellence (CCB, ZM, KAM, LSR, AP, JCT, GMP), Johns Hopkins School of Medicine, Baltimore, MD; Department of Neurology (AB, TMD, CLM, KAM, LSR, AP, GMP), Johns Hopkins School of Medicine, Baltimore MD.
Melissa D ShepardDepartment of Psychiatry and Behavioral Sciences (NMF, JTH, KP, MDS, AB, GMP), Johns Hopkins School of Medicine, Baltimore, MD.
Alexander PantelyatMorris K. Udall Parkinson's Disease Research Center of Excellence (CCB, ZM, KAM, LSR, AP, JCT, GMP), Johns Hopkins School of Medicine, Baltimore, MD; Department of Neurology (AB, TMD, CLM, KAM, LSR, AP, GMP), Johns Hopkins School of Medicine, Baltimore MD.
Arnold BakkerDepartment of Psychiatry and Behavioral Sciences (NMF, JTH, KP, MDS, AB, GMP), Johns Hopkins School of Medicine, Baltimore, MD.
Olga PletnikovaMorris K. Udall Parkinson's Disease Research Center of Excellence (CCB, ZM, KAM, LSR, AP, JCT, GMP), Johns Hopkins School of Medicine, Baltimore, MD; Clinical and Neuropathology Core (MM, OP, JCT), Johns Hopkins School of Medicine, Baltimore, MD.
Juan C TroncosoMorris K. Udall Parkinson's Disease Research Center of Excellence (CCB, ZM, KAM, LSR, AP, JCT, GMP), Johns Hopkins School of Medicine, Baltimore, MD; Clinical and Neuropathology Core (MM, OP, JCT), Johns Hopkins School of Medicine, Baltimore, MD.
Jiangxia WangDepartment of Biostatistics (JW), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.
Gregory M PontoneDepartment of Psychiatry and Behavioral Sciences (NMF, JTH, KP, MDS, AB, GMP), Johns Hopkins School of Medicine, Baltimore, MD; Morris K. Udall Parkinson's Disease Research Center of Excellence (CCB, ZM, KAM, LSR, AP, JCT, GMP), Johns Hopkins School of Medicine, Baltimore, MD; Department of Neurology (AB, TMD, CLM, KAM, LSR, AP, GMP), Johns Hopkins School of Medicine, Baltimore MD. Electronic address: gpontone@jhmi.edu.
Johns Hopkins University · USMaastricht University Medical Centre · NLLou Ruvo Brain Institute · US

Funding

Understanding Mechanisms of a-synuclein pathologyP50NS038377 · NINDS · JOHNS HOPKINS UNIVERSITY · PI DAWSON, TED M. · 1998 to 2019
$38.8M
Medical Scientist Training ProgramT32GM136577 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ANDREA L COX · 2020 to 2026
$13.4M
Astrocyte NLRP3 inflammasome activation in Parkinson's diseaseF30AG067643 · NIA · JOHNS HOPKINS UNIVERSITY · PI HINKLE, JARED · 2020 to 2022
$153k
NIA NIH HHS F30 AG067643NIGMS NIH HHS T32 GM136577NINDS NIH HHS P50 NS038377
6 · The paper itself

Abstract

backgroundThe pathological hallmarks of Parkinson's disease include intraneuronal Lewy bodies, neuronal loss, and gliosis. We aim to correlate Parkinson's disease neuropsychiatric symptoms, (e.g., depression, psychosis, and anxiety) with the severity of neuropathology in the substantia nigra and locus coeruleus.

methodsThe brains of 175 participants with a primary pathologic diagnosis of Parkinson's disease were analyzed semi-quantitatively to ascertain the burden of neuronal loss and gliosis and Lewy body pathology within the locus coeruleus and substantia nigra. Participants' history of anxiety, depression, and psychosis were determined using a chart-extracted medical history or record of formal psychiatric evaluation.

resultsOf the sample, 56% (n = 98), 50% (n = 88), and 31.25% (n = 55) of subjects had a diagnosis of psychosis, depression, and anxiety, respectively. Psychosis (χ

conclusionThese results suggest that psychosis and depression in Parkinson's disease are associated with the underlying neurodegenerative process and demonstrate that cell loss and gliosis may be a better marker of neuropsychiatric symptoms than Lewy body pathology.

Indexed as

Parkinson DiseasePsychotic DisordersBrain StemDepressionHumansLewy BodiesDepressionneuropathologyParkinson's diseasepsychosis

Identifiers

PMID33455856
PMCPMC8277871
OpenAlexW3120369777

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.