ArticleUltrasound in medicine & biology2021
High-Resolution Focused Ultrasound Neuromodulation Induces Limb-Specific Motor Responses in Mice in Vivo.
Article in Ultrasound in medicine & biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Ultrasound Modulation of Visual Circuits in Mice Independent of Auditory Confound.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Imaging of Neurovascular Activity during Motor Responses Evoked by Displacement-guided Focused Ultrasound (DgFUS) Neuromodulation in Mice.Research square · 2026Article
- Displacement-Guided Focused Ultrasound of the Median Nerve Modulates Somatosensory Evoked Potentials in Humans.IEEE transactions on bio-medical engineering · 2026Article
- A panoramic review of transcranial focused ultrasound neuromodulation: from basic research to clinical applications.Journal of neuroengineering and rehabilitation · 2025Review
- Computational sensitivity evaluation of ultrasound neuromodulation resolution to brain tissue sound speed with robust beamforming.Scientific reports · 2025Article
- Optimized ultrasound neuromodulation for non-invasive control of behavior and physiology.Neuron · 2024Article
- The future of transcranial ultrasound as a precision brain interface.PLoS biology · 2024Article
- Displacement and functional ultrasound (fUS) imaging of displacement-guided focused ultrasound (FUS) neuromodulation in mice.NeuroImage · 2024Article
- Functional ultrasound (fUS) imaging of displacement-guided focused ultrasound (FUS) neuromodulation in mice.bioRxiv : the preprint server for biology · 2024Article
- Modulation of cardio-respiratory activity in mice via transcranial focused ultrasound.Ultrasound in medicine & biology · 2024Article
- Model-based correction of rapid thermal confounds in fluorescence neuroimaging of targeted perturbation.Neurophotonics · 2024Article
- A Miniature Ultrasound Source for Neural Modulation.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2023Article
- Computational modeling and minimization of unintended neuronal excitation in a LIFU stimulation.Scientific reports · 2023Article
- Acoustic radiation force for analyzing the mechanical stress in ultrasound neuromodulation.Physics in medicine and biology · 2023Article
- Phase-Optimized Multi-Step Phase Acoustic Metasurfaces for Arbitrary Multifocal Beamforming.Micromachines · 2023Article
- The mechanosensitive ion channel Piezo1 contributes to ultrasound neuromodulation.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Mechanics Of Ultrasonic Neuromodulation In A Mouse Subject.Extreme Mechanics Letters · 2022Article
- High resolution ultrasonic neural modulation observed via in vivo two-photon calcium imaging.Brain stimulationArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Ultrasound can modulate activity in the central nervous system, including the induction of motor responses in rodents. Recent studies investigating ultrasound-induced motor movements have described mostly bilateral limb responses, but quantitative evaluations have failed to reveal lateralization or differences in response characteristics between separate limbs or how specific brain targets dictate distinct limb responses. This study uses high-resolution focused ultrasound (FUS) to elicit motor responses in anesthetized mice in vivo and four-limb electromyography (EMG) to evaluate the latency, duration and power of paired motor responses (n = 1768). The results indicate that FUS generates target-specific differences in electromyographic characteristics and that brain targets separated by as little as 1 mm can modulate the responses in individual limbs differentially. Exploiting these differences may provide a tool for quantifying the susceptibility of underlying neural volumes to FUS, understanding the functioning of the targeted neuroanatomy and aiding in mechanistic studies of this non-invasive neuromodulation technique.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.