Evidence map›Paper›PMID 33455472›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2021

Thiophen urea derivatives as a new class of hepatitis C virus entry inhibitors.

Hyung Chul Ryu, Marc Windisch, Jee Woong Lim, Inhee Choi, Eun Kyu Lee, Hye Hyun Yoo, Tae Kon Kim

RetractedAbstract readRetracted Publication
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Entry Inhibitors of Hepatitis C Virus.Advances in experimental medicine and biology · 2022
    Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Hyung Chul RyuR&D Center, J2H Biotech, Suwon, Gyeonggi-do, Republic of Korea.
Marc WindischMedicinal Chemistry, Institut Pasteur Korea, Seongnam, Gyeonggi-do, Republic of Korea.
Jee Woong LimR&D Center, J2H Biotech, Suwon, Gyeonggi-do, Republic of Korea.
Inhee ChoiMedicinal Chemistry, Institut Pasteur Korea, Seongnam, Gyeonggi-do, Republic of Korea.
Eun Kyu LeeInstitute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University, Ansan, Gyeonggi-do, Republic of Korea.
Hye Hyun YooInstitute of Pharmaceutical Science and Technology and College of Pharmacy, Hanyang University, Ansan, Gyeonggi-do, Republic of Korea.
Tae Kon KimCollege of Science and Engineering, Jungwon University, Geosan-gun, Chungbuk, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To develop unique small-molecule inhibitors of hepatitis C virus (HCV), thiophen urea (TU) derivatives were synthesised and screened for HCV entry inhibitory activities. Among them, seven TU compounds exhibited portent anti-viral activities against genotypes 1/2 (EC

Indexed as

Antiviral AgentsDose-Response Relationship, DrugHepacivirusMicrobial Sensitivity TestsMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipThiophenesUreaViral Envelope ProteinsVirus InternalizationAntiviral Agentsglycoprotein E2, Hepatitis C virusThiophenesUreaViral Envelope ProteinsEntry inhibitorhepatitis C virussmall moleculethiophen urea

Identifiers

PMID33455472
PMCPMC7822064

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.