Evidence map›Paper›PMID 33455217›Full record

ArticleACS biomaterials science & engineering2020

Gap Junction Liposomes for Efficient Delivery of Chemotherapeutics to Solid Tumors.

Andrea N Trementozzi, Stephanie Hufnagel, Haiyue Xu, Mahmoud S Hanafy, Felipe Rosero Castro, Hugh D C Smyth, Zhengrong Cui, Jeanne C Stachowiak

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS biomaterials science & engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Light-Activated Assembly of Connexon Nanopores in Synthetic Cells.Journal of the American Chemical Society · 2023
    Article
  6. Article
  7. Gap Junction-Mediated Delivery of Polymeric Macromolecules.ACS biomaterials science & engineering · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Andrea N TrementozziDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, Texas 78712, United States.
Stephanie HufnagelCollege of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, United States.
Haiyue XuCollege of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, United States.
Mahmoud S HanafyCollege of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, United States.ORCID 0000-0002-5090-883X
Felipe Rosero CastroDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, Texas 78712, United States.
Hugh D C SmythCollege of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, United States.
Zhengrong CuiCollege of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, United States.ORCID 0000-0002-1789-910X
Jeanne C StachowiakDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, Texas 78712, United States.ORCID 0000-0003-2501-142X
The University of Texas at Austin · US

Funding

Harnessing the gap junction network for direct intracellular delivery of siRNA and chemotherapeuticsR21EB025490 · NIBIB · UNIVERSITY OF TEXAS AT AUSTIN · PI SMYTH, HUGH DAVID, STACHOWIAK, JEANNE CASSTEVENS · 2018 to 2019
$416k
NIBIB NIH HHS R21 EB025490
6 · The paper itself

Abstract

Chemotherapeutic delivery is limited by inefficient transport across cellular membranes. Here, we harness the cellular gap junction network to release therapeutic cargos directly into the cytosol. Specifically, cell-derived vesicles, termed connectosomes, contain gap junction transmembrane proteins that open a direct passageway to the cellular interior. Connectosomes were previously shown to substantially improve chemotherapeutic delivery

Indexed as

LiposomesNeoplasmsAnimalsCell MembraneConnexinsGap JunctionsMiceConnexinsLiposomesdeliverygap junction channelsintracellularintratumoralmurine mammary tumor

Identifiers

PMID33455217
PMCPMC8483596
OpenAlexW3079783440

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.