Evidence map›Paper›PMID 33455057›Full record

ArticleCancer medicine2021

Association between blood pressure and BMI with bladder cancer risk and mortality in 340,000 men in three Swedish cohorts.

Stanley Teleka, Sylvia H J Jochems, Christel Häggström, Angela M Wood, Bengt Järvholm, Marju Orho-Melander, Fredrik Liedberg, Tanja Stocks

Open access · goldAbstract read
In one paragraph

Article in Cancer medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 4 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 4 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
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  3. Effects of physical exercise on body fat and laboratory biomarkers in cancer patients: a meta-analysis of 35 randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Pooled it
  4. Pooled it
  5. Urolithiasis in patients with cancer.Nature reviews. Urology · 2026
    Review
  6. Turkish urologists' knowledge and attitudes on lifestyle advice for bladder cancer: a national survey.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Stanley TelekaDepartment of Clinical Sciences in Lund, Lund University, Lund, Sweden.ORCID 0000-0002-9343-8399
Sylvia H J JochemsDepartment of Clinical Sciences in Lund, Lund University, Lund, Sweden.ORCID 0000-0001-7676-1488
Christel HäggströmDepartment of Biobank Research, Umeå University, Umeå, Sweden.ORCID 0000-0001-6808-4405
Angela M WoodMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Bengt JärvholmDepartment of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Marju Orho-MelanderDepartment of Clinical Sciences in Malmö, Lund University, Lund, Sweden.
Fredrik LiedbergDivision of Urological Research, Institution of Translational Medicine, Lund University, Malmö, Sweden.
Tanja StocksDepartment of Clinical Sciences in Lund, Lund University, Lund, Sweden.
Lund University · SEUmeå University · SEUniversity of Cambridge · GBUppsala University · SE

Funding

Medical Research Council G0701619Medical Research Council MR/K014811/1
6 · The paper itself

Abstract

backgroundThe relation between obesity, blood pressure (BP) and bladder cancer (BC) risk and mortality remains unclear, partially due to potential confounding by smoking, the strongest risk factor for BC, and not accounting for tumor stage and grade in such studies. We investigated body mass index (BMI) and BP in relation to BC risk by stage and grade, and BC-specific mortality, including separately among never-smokers aimed at minimizing confounding by smoking.

methodsWe analyzed 338,910 men from three Swedish cohorts, with 4895 incident BC's (940 among never-smokers) during follow-up. Cox regression was used to calculate hazard ratios (HR) and 95% confidence intervals adjusted for smoking status. HRs for BMI and BP were corrected for their regression dilution ratios, calculated from 280,456 individuals with 758,641 observations.

resultsBody mass index was positively associated with non-muscle invasive BC (NMIBC, HR per 5 kg/m

conclusionsIn an analyses of BMI, BP and BC risk by stage and grade among men, we found modest positive associations between BMI and NMIBC and NMIBC grade 3. SBP was positively associated with MIBC and BC-specific mortality in an analysis of never-smokers, which may reflect the association, un-confounded by smoking, also in a broader population.

Indexed as

Blood PressureBody Mass IndexAdultCohort StudiesFollow-Up StudiesHumansMalePrognosisRisk FactorsSurvival RateSwedenUrinary Bladder Neoplasmsbladder cancerblood pressurebody mass indexconfoundingsurvival analysis

Identifiers

PMID33455057
PMCPMC7926028
OpenAlexW3123344223

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.