Evidence map›Paper›PMID 33454928›Full record

ArticleInfection2021

Concurrent cavitary pulmonary tuberculosis and COVID-19 pneumonia with in vitro immune cell anergy.

Maria Musso, Francesco Di Gennaro, Gina Gualano, Silvia Mosti, Carlotta Cerva, Saeid Najafi Fard, Raffaella Libertone, Virginia Di Bari, Massimo Cristofaro, Roberto Tonnarini and 3 more

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in Infection, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Status and outlook of pulmonary tuberculosis coinfection.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2025
    Review
  3. Article
  4. Diverse interactions ofFrontiers in tuberculosis · 2024
    Review
  5. Review
  6. Initial immune response after exposure toFrontiers in immunology · 2023
    Review
  7. Multiple CD59 Polymorphisms in Chinese Patients withJournal of immunology research · 2023
    Article
  8. Review
  9. Tuberculosis Disability Adjusted Life Years, Colombia 2010-2018.Tropical medicine and infectious disease · 2022
    Article
  10. Article
  11. Infectious disease reports · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Coinfection of tuberculosis and COVID-19 limits the ability to in vitro respond to SARS-CoV-2.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021
    Article
  18. Review
  19. Article
  20. Frontiers in microbiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 2 countries.

Maria MussoRespiratory Infectious Diseases Unit, National Institute for Infectious Diseases "L. Spallanzani" IRCCS, Rome, Italy. maria.musso@inmi.it.ORCID http://orcid.org/0000-0001-5663-7906
Francesco Di GennaroRespiratory Infectious Diseases Unit, National Institute for Infectious Diseases "L. Spallanzani" IRCCS, Rome, Italy.
Gina GualanoRespiratory Infectious Diseases Unit, National Institute for Infectious Diseases "L. Spallanzani" IRCCS, Rome, Italy.
Silvia MostiRespiratory Infectious Diseases Unit, National Institute for Infectious Diseases "L. Spallanzani" IRCCS, Rome, Italy.
Carlotta CervaRespiratory Infectious Diseases Unit, National Institute for Infectious Diseases "L. Spallanzani" IRCCS, Rome, Italy.
Saeid Najafi FardTranslational Research Unit, National Institute for Infectious Diseases "L. Spallanzani", IRCCS, Rome, Italy.
Raffaella LibertoneRespiratory Infectious Diseases Unit, National Institute for Infectious Diseases "L. Spallanzani" IRCCS, Rome, Italy.
Virginia Di BariRespiratory Infectious Diseases Unit, National Institute for Infectious Diseases "L. Spallanzani" IRCCS, Rome, Italy.
Massimo CristofaroDiagnostic Imaging Unit, National Institute of Infectious Diseases "L. Spallanzani", IRCCS, Rome, Italy.
Roberto TonnariniRespiratory Infectious Diseases Unit, National Institute for Infectious Diseases "L. Spallanzani" IRCCS, Rome, Italy.
Concetta CastillettiLaboratory of Virology, National Institute of Infectious Diseases "L. Spallanzani", IRCCS, Rome, Italy.
Delia GolettiTranslational Research Unit, National Institute for Infectious Diseases "L. Spallanzani", IRCCS, Rome, Italy.
Fabrizio PalmieriRespiratory Infectious Diseases Unit, National Institute for Infectious Diseases "L. Spallanzani" IRCCS, Rome, Italy.
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani · IT

Funding

Ministero della Salute (IT) Ricerca Corrente, Research programme n.4: tuberculosis.
6 · The paper itself

Abstract

Tuberculosis (TB) is top infectious disease killer caused by a single organism responsible for 1.5 million deaths in 2018. Both COVID-19 and the pandemic response are risking to affect control measures for TB and continuity of essential services for people affected by this infection in western countries and even more in developing countries. Knowledge about concomitant pulmonary TB and COVID-19 is extremely limited. The double burden of these two diseases can have devastating effects. Here, we describe from both the clinical and the immunological point of view a case of a patient with in vitro immune cell anergy affected by bilateral cavitary pulmonary TB and subsequent COVID-19-associated pneumonia with a worst outcome. COVID-19 can be a precipitating factor in TB respiratory failure and, during ongoing SARS-COV-2 pandemic, clinicians must be aware of this possible co-infection in differential diagnosis of patients with active TB and new or worsening chest imaging.

Indexed as

COVID-19TuberculosisTuberculosis, PulmonaryHumansPandemicsSARS-CoV-2COVID-19IGRA testSARS-CoV-2Tuberculosis

Identifiers

PMID33454928
PMCPMC7811686
OpenAlexW3121874636

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.