Evidence map›Paper›PMID 33454868›Full record

ReviewInvestigational new drugs2021

Gut microbiota homeostasis restoration may become a novel therapy for breast cancer.

Zhi-Peng Feng, Hong-Yi Xin, Ze-Wei Zhang, Chen-Guang Liu, Zheng Yang, Hua You, Hong-Wu Xin

Abstract readReview
PubMed Publisher
In one paragraph

Review in Investigational new drugs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Zhi-Peng Feng *Department of Infectious disease, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, No. 60 Jingzhong Road, Jingzhou District, Jingzhou, 434020, Hubei Province, China.ORCID 0000-0003-3342-4558
Hong-Yi Xin *Department of Microbiology and Immunology, Immunology Programe, Yong Loo Lin School of Medicine, National University of Singapore, Center for Life Sciences, 28 Medical Drive, #03-09, Singapore, 117456, Singapore.
Ze-Wei Zhang *The Fourth Affiliated Hospital, China Medical University, Shenyang, 110000, Liaoning, China.
Chen-Guang LiuLaboratory of Oncology, Center for Molecular Medicine, School of Basic Medicine, Health Science Center, Yangtze University, 1 Nanhuan Road, Jingzhou, 434023, Hubei, China.
Zheng YangDepartment of Infectious disease, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, No. 60 Jingzhong Road, Jingzhou District, Jingzhou, 434020, Hubei Province, China. yangzheng_0809@163.com.
Hua YouAffiliated Cancer Hospital and Institute of Guangzhou Medical University, No.78 Heng-Zhi-Gang Road, Yue Xi District, Guangzhou, 510095, China. Youhua307@163.com.
Hong-Wu XinDepartment of Infectious disease, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, No. 60 Jingzhong Road, Jingzhou District, Jingzhou, 434020, Hubei Province, China. hongwu_xin@126.com.
Yangtze University · CNNational University of Singapore · SGFourth Affiliated Hospital of China Medical University · CNGuangzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer is the most diagnosed cancer in women. It significantly impairs a patient's physical and mental health. Gut microbiota comprise the bacteria residing in a host's gastrointestinal tract. Through studies over the last decade, we now know that alterations in the composition of the gut microbiome are associated with protection against colonization by pathogens and other diseases, such as diabetes and cancer. This review focuses on how gut microbiota can affect breast cancer development through estrogen activity and discusses the types of bacteria that may be involved in the onset and the progression of breast cancer. We also describe potential therapies to curtail the risk of breast cancer by restoring gut microbiota homeostasis and reducing systemic estrogen levels. This review will further explore the relationship between intestinal microbes and breast cancer and propose a method to treat breast cancer by improving intestinal microbes. We aimed at discovering new methods to prevent or treat BC by changing intestinal microorganisms.

Indexed as

Gastrointestinal MicrobiomeBreast NeoplasmsDysbiosisEstrogensFemaleHomeostasisHumansEstrogensBreast cancerGut microbiotaHomeostasisNovel therapy

Identifiers

PMID33454868
OpenAlexW3125419775

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.