Evidence map›Paper›PMID 33454860›Full record

ArticleInternational urology and nephrology2021

The prevalence and associated factors of nonadherence to antihypertensive medication in secondary healthcare.

Renata Romanholi Pinhati, Renato Erothildes Ferreira, Moisés Carminatti, Paula Liziero Tavares, Elisa Oliveira Marsicano, Emiliana Spadarotto Sertório, Fernando Antonio Basile Colugnati, Rogério Baumgratz de Paula, Helady Sanders-Pinheiro

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In one paragraph

Article in International urology and nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Low income and health literacy: a systematic scoping review.Archives of public health = Archives belges de sante publique · 2025
    Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Renata Romanholi PinhatiDivision of Nephrology, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.
Renato Erothildes FerreiraDivision of Nephrology, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.
Moisés CarminattiDivision of Nephrology, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.
Paula Liziero TavaresDivision of Nephrology, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.
Elisa Oliveira MarsicanoDivision of Nephrology, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.
Emiliana Spadarotto SertórioDivision of Nephrology, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.
Fernando Antonio Basile ColugnatiDivision of Nephrology, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.
Rogério Baumgratz de PaulaDivision of Nephrology, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil.
Helady Sanders-PinheiroDivision of Nephrology, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil. heladysanders@gmail.com.ORCID http://orcid.org/0000-0001-8603-1331
Universidade Federal de Juiz de Fora · BR

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001
6 · The paper itself

Abstract

purposeNon-adherence (NA) to medication is a major contributor to treatment failure in hypertensive patients. Factors of the ecological model, at family/healthcare professional, service, and system levels, are rarely evaluated as correlates of NA in hypertensive patients.

methodsThis crossectional study assessed the prevalence of and associated factors of NA to antihypertensive medication among 485 hypertensive patients upon receiving secondary healthcare. The Morisky Green Levine Scale (MGLS) measured the implementation phase of adherence, and the Short Assessment of Health Literacy for Portuguese-speaking Adults (SAHLPA) instrument, health literacy. Multivariate analysis to NA included variables according to the levels of the ecological model.

resultsMost patients were female (56.3%), white (53.2%), mean age of 62.0 ± 12.6 years, illiterate (61.6%), with low health literacy (70.9%), and low income (65.4%). Uncontrolled BP was frequent (75.2%); 57.1% of patients were nonadherent. In multivariate analysis based on the ecological model, adjusted for micro, meso- and macro-level correlates, NA was associated only with variables of patient-level: low health literacy (OR 1.62, CI 1.07-2.44, p = 0.020), income ≥ two reference wages (OR 0.46, CI 0.22-0.93, p = 0.031), lack of homeownership (OR 1.99, CI 1.13-3.51, p = 0.017), sedentarism (OR 1.78, CI 1.12-2.83, p = 0.014), and complexity of treatment (number of medications taken ≥ two times/day) (OR 1.56, CI 1.01-2.41, p = 0.042).

conclusionIn this group of severely hypertensive patients with high cardiovascular risk, only patient-related characteristics were associated with NA. Our findings highlight the need for effective actions to optimize clinical outcomes in similar healthcare programs.

Indexed as

Drug MonitoringAgedAntihypertensive AgentsCross-Sectional StudiesFemaleHumansHypertensionMaleMiddle AgedSecondary Health CareAntihypertensive AgentsAntihypertensive drugsHealthcareHypertensionMedication nonadherenceMultilevel analysis

Identifiers

PMID33454860
OpenAlexW3123564507

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.