ReviewVirchows Archiv : an international journal of pathology2021
Primary MiNEN of the urinary bladder: an hitherto undescribed entity composed of large cell neuroendocrine carcinoma and adenocarcinoma with a distinct clinical behavior : Description of a case and review of the pertinent literature.
Review in Virchows Archiv : an international journal of pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 11 citations in OpenAlex.
- Neuroendocrine Neoplasms of the Urinary Bladder: Integrating Molecular Advances into a Refined Classification System.Endocrine pathology · 2026Review
- Mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN) of the foreskin: a case report and literature review.Virchows Archiv : an international journal of pathology · 2026Article
- Primary MiNEN of the urinary bladder with large cell neuroendocrine carcinoma and enteric-type adenocarcinoma: a case report.Frontiers in oncology · 2026Article
- Prognostic Factors Influencing Postoperative Survival in Patients With Neuroendocrine Carcinoma of the Bladder: A Population-Based Study.Cancer medicine · 2025Article
- Mixed neuroendocrine-nonneuroendocrine epithelial neoplasm of muscle invasive bladder cancer: a clinicopathologic case study.Journal of surgical case reports · 2024Article
- Ureter mixed neuroendocrine-non-neuroendocrine neoplasm: a case report and literature review.Frontiers in oncology · 2024Article
- Primary pure large cell neuroendocrine carcinoma of the urinary bladder: a case report and literature review.Frontiers in oncology · 2024Article
- Mixed Neuroendocrine/Non-neuroendocrine Neoplasm (MiNEN) of the Ovary Arising from Endometriosis: Molecular Pathology Analysis in Support of a Pathogenetic Paradigm.Endocrine pathology · 2022Article
- The classification of neuroendocrine neoplasms of the breast and its clinical relevance.Virchows Archiv : an international journal of pathology · 2022Review
- A Case of Bladder Large Cell Carcinoma with Review of the Literature.Case reports in oncologyArticle
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuroendocrine carcinomas (NECs) of the urinary bladder are very rare and can be observed in the context of mixed neuroendocrine/non-neuroendocrine neoplasms (MiNENs), most frequently in association with urothelial carcinoma. Small cell NECs are far more common than large cell NECs (LCNECs), which are exceedingly rare. We describe a primary MiNEN of the urinary bladder, composed of a LCNEC and of an adenocarcinoma, in which the neuroendocrine component reached complete pathological regression after neoadjuvant M-VAC chemotherapy, whereas the non-neuroendocrine component of the tumor progressed to metastatic disease. Compared to mixed neuroendocrine/non-neuroendocrine neoplasms described in the literature until now, this appears to be a unique case that expands the spectrum of neuroendocrine neoplasia of the urinary bladder.
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