Observational studyDiabetologia2021
Poor glycaemic control is associated with increased risk of neurodevelopmental disorders in childhood-onset type 1 diabetes: a population-based cohort study.
Observational study in Diabetologia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Association between type 1 diabetes and neurodevelopmental disorders in children and adolescents: A systematic review and meta-analysis.Frontiers in psychiatry · 2022Pooled it
- Shared genetic architecture between psychiatric and insulin-related traits in the general population.Neuroscience applied · 2026Article
- Unraveling the Interplay Between Metabolism and Neurodevelopment in Health and Disease.CNS neuroscience & therapeutics · 2025Review
- Article
- Comorbidity of Type 1 Diabetes and ADHD: A Longitudinal Cohort Study in Males and Females From the Norwegian Childhood Diabetes Registry.Pediatric diabetes · 2025Article
- Article
- Psychotropic Medication Use in Children and Adolescents With Type 1 Diabetes.JAMA network open · 2023Article
- Influence of Maternal Diabetes on the Risk of Neurodevelopmental Disorders in Offspring in the Prenatal and Postnatal Periods.Diabetes & metabolism journal · 2022Article
- Diabetes and associated cognitive disorders: Role of the Hypothalamic-Pituitary Adrenal axis.Metabolism open · 2022Review
- Impact of glucose metabolism on the developing brain.Frontiers in endocrinology · 2022Review
- Neurodevelopmental Disorders, Glycemic Control, and Diabetic Complications in Type 1 Diabetes: a Nationwide Cohort Study.The Journal of clinical endocrinology and metabolism · 2021Article
- Psychosocial factors affecting the etiology and management of type 1 diabetes mellitus: A narrative review.World journal of diabetes · 2021Review
- ADHD should be considered in adolescents with type 1 diabetes and poor metabolic control.Diabetologia · 2021Article
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Authors and funding
10 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisThe aim of this study was to investigate the effect of childhood-onset type 1 diabetes on the risk of subsequent neurodevelopmental disorders, and the role of glycaemic control in this association. We hypothesised that individuals with poor glycaemic control may be at a higher risk of neurodevelopmental disorders compared with the general population, as well as compared with individuals with type 1 diabetes with adequate glycaemic control.
methodsThis Swedish population-based cohort study was conducted using data from health registers from 1973 to 2013. We identified 8430 patients with childhood-onset type 1 diabetes (diagnosed before age 18 years) with a median age of diabetes onset of 9.6 (IQR 5.9-12.9) and 84,300 reference individuals from the general population, matched for sex, birth year and birth county. Cox models were used to estimate the effect of HbA
resultsDuring a median follow-up period of 5.6 years, 398 (4.7%) individuals with type 1 diabetes received a diagnosis of any neurodevelopmental disorder compared with 3066 (3.6%) in the general population, corresponding to an adjusted HR (HR CONCLUSIONS/
interpretationChildhood-onset type 1 diabetes is associated with an increased risk of neurodevelopmental disorders, with the highest risk seen in individuals with poor glycaemic control. Routine neurodevelopmental follow-up visits should be considered in type 1 diabetes, especially in patients with poor glycaemic control.
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