Evidence map›Paper›PMID 33454813›Full record

ArticleWorld journal of urology2021

Prospective trial of regional (hockey-stick) prostate cryoablation: oncologic and quality of life outcomes.

Justin R Gregg, Leonardo D Borregales, Haesun Choi, Marisa Lozano, Stephen E McRae, Aradhana M Venkatesan, John W Davis, Graciela M Nogueras-Gonzalez, Louis L Pisters, John F Ward

Open access · greenAbstract readControlled Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of urology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Current Status of Cryoablation in Prostate Cancer Management.Clinical Medicine Insights. Oncology · 2025
    Review
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Justin R GreggDepartment of Urology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Av. Unit 1373, Houston, TX, 77030, USA. JRGregg@mdanderson.org.
Leonardo D BorregalesDepartment of Urology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Av. Unit 1373, Houston, TX, 77030, USA.
Haesun ChoiDivision of Diagnostic Imaging, Department of Abdominal Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Marisa LozanoDepartment of Urology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Av. Unit 1373, Houston, TX, 77030, USA.
Stephen E McRaeDepartment of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Aradhana M VenkatesanDivision of Diagnostic Imaging, Department of Abdominal Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
John W DavisDepartment of Urology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Av. Unit 1373, Houston, TX, 77030, USA.
Graciela M Nogueras-GonzalezDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Louis L PistersDepartment of Urology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Av. Unit 1373, Houston, TX, 77030, USA.
John F WardDepartment of Urology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Av. Unit 1373, Houston, TX, 77030, USA.
The University of Texas MD Anderson Cancer Center · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
Targeting Tumor Microenvironment-Induced Therapy Resistance in Prostate Cancer Bone MetastasisP50CA140388 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI THOMPSON, TIMOTHY CHARLES · 2009 to 2022
$23.4M
NCI NIH HHS P30 CA016672NCI NIH HHS P50 CA140388
6 · The paper itself

Abstract

purposeTo report long-term follow-up of the efficacy of subtotal prostate ablation using a "hockey-stick" template, including oncologic control and quality of life (QoL) impact.

methodsWe performed a prospective controlled trial to evaluate the efficacy of subtotal prostate ablation in selected men with baseline and confirmatory biopsy showing grade group (GG) 1-2 prostate cancer. "Hockey-stick" cryoablation that included the ipsilateral hemi-gland and contralateral anterior prostate was performed. Prostate biopsies and QOL queries were performed at 6, 18 and 36 months following regional ablation, and follow-up was updated to include subsequent clinic visits.

resultsBetween August 2009 and January 2012, 72 men were screened for eligibility and 47 opted to undergo confirmatory biopsy. Of these, 23 were deemed eligible and treated with regional cryoablation. Median age was 64 years. Median follow-up was 74 months. A single patient had < 1 mm of in-field viable tumor with therapy effect on 36-month biopsy. At time of last follow-up, a total of 12/23 (52%) patients did not have evidence of disease, all patients had preserved urinary control with no patients requiring pads for urinary incontinence. Sexual decline was significant at 3 and 6 months (P < 0.01 for both), though improvement was seen at subsequent time points.

conclusionSubtotal (hockey-stick template) cryoablation of the prostate provides oncologic control to targeted tissue in a generally low-risk group with minimal impact on sexual and urinary function. Further studies are needed to evaluate this ablation template in the MRI-targeted era and higher risk populations.

Indexed as

Quality of LifeAgedCryosurgeryFollow-Up StudiesHumansMaleMiddle AgedProspective StudiesProstatectomyProstatic NeoplasmsTreatment OutcomeCryotherapyFocal ablationOrgan-preserving therapyProstate cancerProstate cryoablationQuality of life

Identifiers

PMID33454813
PMCPMC9810085
OpenAlexW3122438926

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.