Evidence map›Paper›PMID 33454749›Full record

ReviewBriefings in functional genomics2021

Deciphering RNA modifications at base resolution: from chemistry to biology.

Turja K Debnath, Blerta Xhemalçe

Abstract readReview
In one paragraph

Review in Briefings in functional genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. NAT10 andScience advances · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Turja K DebnathDepartment of Molecular Biosciences, University of Texas at Austin, 2500 Speedway, 78712 Austin TX, USA.
Blerta XhemalçeDepartment of Molecular Biosciences, University of Texas at Austin, 2500 Speedway, 78712 Austin TX, USA.

Funding

Elucidating mechanisms of microRNA pathway deregulation in human cellsR01GM127802 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI XHEMALCE, BLERTA · 2018 to 2022
$1.7M
NIGMS NIH HHS R01 GM127802
6 · The paper itself

Abstract

Nearly 200 distinct chemical modifications of RNAs have been discovered to date. Their analysis via direct methods has been possible in abundant RNA species, such as ribosomal, transfer or viral RNA, since several decades. However, their analysis in less abundant RNAs species, especially cellular messenger RNAs, was rendered possible only recently with the advent of high throughput sequencing techniques. Given the growing biomedical interest of the proteins that write, erase and read RNA modifications, ingenious new methods to enrich and identify RNA modifications at base resolution have been implemented, and more efforts are underway to render them more quantitative. Here, we review several crucial modification-specific (bio)chemical approaches and discuss their advantages and shortcomings for exploring the epitranscriptome.

Indexed as

RNARNA Processing, Post-TranscriptionalBiologyHigh-Throughput Nucleotide SequencingRNA, MessengerRNA, ViralRNARNA, MessengerRNA, ViralacetylationepitranscriptomemethodmethylationRNA modificationssequencing

Identifiers

PMID33454749
PMCPMC8008165

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.