Evidence map›Paper›PMID 33454424›Full record

ArticleMatrix biology : journal of the International Society for Matrix Biology2021

The versican-hyaluronan complex provides an essential extracellular matrix niche for Flk1

Sumeda Nandadasa, Anna O'Donnell, Ayako Murao, Yu Yamaguchi, Ronald J Midura, Lorin Olson, Suneel S Apte

Open access · greenAbstract read
In one paragraph

Article in Matrix biology : journal of the International Society for Matrix Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. Concurrent Wagner syndrome and retinopathy of prematurity.American journal of ophthalmology case reports · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Proteolysis: a key post-translational modification regulating proteoglycans.American journal of physiology. Cell physiology · 2022
    Review
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Sumeda NandadasaDepartment of Biomedical Engineering (ND20), Cleveland Clinic Lerner Research Institute, 9500 Euclid Avenue, Cleveland, OH 44195, United States.
Anna O'DonnellDepartment of Biomedical Engineering (ND20), Cleveland Clinic Lerner Research Institute, 9500 Euclid Avenue, Cleveland, OH 44195, United States.
Ayako MuraoHuman Genetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, United States.
Yu YamaguchiHuman Genetics Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, United States.
Ronald J MiduraDepartment of Biomedical Engineering (ND20), Cleveland Clinic Lerner Research Institute, 9500 Euclid Avenue, Cleveland, OH 44195, United States.
Lorin OlsonCardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, United States.
Suneel S ApteDepartment of Biomedical Engineering (ND20), Cleveland Clinic Lerner Research Institute, 9500 Euclid Avenue, Cleveland, OH 44195, United States. Electronic address: aptes@ccf.org.
Cleveland Clinic Lerner College of Medicine · USSanford Burnham Prebys Medical Discovery Institute · USOklahoma Medical Research Foundation · US

Funding

VERSICAN PROTEOLYSIS AND REGULATION OF VASCULAR SMOOTH MUSCLEP01HL107147 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI HASCALL, VINCENT CHARLES · 2011 to 2017
$16.1M
Hyaluronan in brain extracellular space as a regulator of glymphatic clearance of AbetaRF1AG057579 · NIA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI YAMAGUCHI, YU · 2017 to 2017
$2.4M
Spinning Disk Confocoal MicroscopeS10RR026820 · NCRR · CLEVELAND CLINIC LERNER COM-CWRU · PI DRAZBA, JUDY · 2010 to 2010
$500k
NCRR NIH HHS S10 RR026820NHLBI NIH HHS P01 HL107147NIA NIH HHS RF1 AG057579
6 · The paper itself

Abstract

Little is known about extracellular matrix (ECM) contributions to formation of the earliest cell lineages in the embryo. Here, we show that the proteoglycan versican and glycosaminoglycan hyaluronan are associated with emerging Flk1

Indexed as

AnimalsCell DifferentiationCells, CulturedCRISPR-Cas SystemsExtracellular MatrixHedgehog ProteinsHematopoiesisHyaluronic AcidMembrane ProteinsMiceMouse Embryonic Stem CellsStem Cell NicheUp-RegulationVascular Endothelial Growth Factor Receptor-2VersicansHedgehog ProteinsHyaluronic Acidihh protein, mouseKdr protein, mouseMembrane ProteinsTmem2 protein, mouseVascular Endothelial Growth Factor Receptor-2Vcan protein, mouseVersicansAngiogenesisEndotheliumHematopoiesis CRISPR-Cas9ProteoglycanVasculogenesis

Identifiers

PMID33454424
PMCPMC8039968
OpenAlexW3119767369

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.