ArticleJACC. Cardiovascular imaging2021
Targeted Coronary Artery Calcium Screening in High-Risk Younger Individuals Using Consumer Genetic Screening Results.
Article in JACC. Cardiovascular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Association between frailty and depression in older adults with coronary heart disease: a systematic review and meta-analysis.Frontiers in public health · 2026Pooled it
- Association between healthy plant-based diet-lifestyle (hPDI-Lifestyle) score and incidence of coronary heart disease, and effect modification by genetic predisposition: a prospective analysis in a population-based cohort.The Lancet regional health. Europe · 2026Article
- Angiographic Burden of Coronary Atherosclerosis Partially Mediates the Association Between ASCVD Risk Factors and Outcomes.Circulation. Genomic and precision medicine · 2026Article
- Unraveling the genetic blueprint of coronary artery disease: The role of polygenic risk scores in risk prediction.American heart journal plus : cardiology research and practice · 2026Article
- Coronary artery calcium in a 20-year-old South Asian patient - pushing the limits of detecting "early disease".American journal of preventive cardiology · 2025Article
- Polygenic Risk Scores and Extreme Coronary Artery Calcium Phenotypes (CAC=0 and CAC≥1000) in Adults ≥75 Years Old: The ARIC Study.Circulation. Cardiovascular imaging · 2024Article
- Polygenic risk score in comparison with C-reactive protein for predicting incident coronary heart disease.Atherosclerosis · 2023Article
- Observational
- An update on the coronary calcium score: a review for clinicians.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2022Review
- Distribution of Coronary Artery Calcium by Age, Sex, and Race Among Patients 30-45 Years Old.Journal of the American College of Cardiology · 2022Article
- Impact of polygenic risk communication: an observational mobile application-based coronary artery disease study.NPJ digital medicine · 2022Article
- Predictors of Coronary Artery Calcium and Long-Term Risks of Death, Myocardial Infarction, and Stroke in Young Adults.Journal of the American Heart Association · 2021Article
- Modeling the Recommended Age for Initiating Coronary Artery Calcium Testing Among At-Risk Young Adults.Journal of the American College of Cardiology · 2021Article
- Polygenic Risk Score to Identify Subclinical Coronary Heart Disease Risk in Young Adults.Circulation. Genomic and precision medicine · 2021Article
- Monogenic and Polygenic Models of Coronary Artery Disease.Current cardiology reports · 2021Review
- Association of polygenic risk scores with incident atherosclerotic cardiovascular disease events among individuals with coronary artery calcium score of zero: The multi-ethnic study of atherosclerosis.Progress in cardiovascular diseasesReview
- The use of coronary artery calcium scoring in young adults.Journal of cardiovascular computed tomographyReview
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesThe goal of this study was to assess the utility of a genetic risk score (GRS) in targeted coronary artery calcium (CAC) screening among young individuals.
backgroundEarly CAC screening and preventive therapy may reduce long-term risk of a coronary heart disease (CHD) event. However, identifying younger individuals at increased risk remains a challenge. GRS for CHD are age independent and can stratify individuals on various risk trajectories.
methodsUsing 142 variants associated with CHD events, we calculated a GRS in 1,927 individuals in the CARDIA (Coronary Artery Risk Development in Young Adults) cohort (aged 32 to 47 years) and 6,600 individuals in the MESA (Multi-Ethnic Study of Atherosclerosis) cohort (aged 44 to 87 years). We assessed GRS utility to predict CAC presence in the CARDIA cohort and stratify individuals of varying risk for CAC presence over the lifetime in both cohorts.
resultsThe GRS predicted CAC presence in CARDIA males. It was not predictive in CARDIA females, which had a CAC prevalence of 6.4%. In combined analysis of the CARDIA and MESA cohorts, the GRS was predictive of CAC in both males and females and was used to derive an equation for the age at which CAC probability crossed a predetermined threshold. When assessed in combination with traditional risk factors, the GRS further stratified individuals. For individuals with an equal number of traditional risk factors, probability of CAC reached 25% approximately 10 years earlier for those in the highest GRS quintile compared to the lowest.
conclusionsThe GRS may be used to target high-risk younger individuals for early CAC screening.
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