ArticleDevelopmental cognitive neuroscience2021
Far and wide: Associations between childhood socio-economic status and brain connectomics.
Article in Developmental cognitive neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Geographic Measures of Early Life-Course Social Exposome in the Evaluation of Structural Neuroanatomy: A Scoping Review.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Review
- Cognitive and neuropsychomotor development in craniosynostosis: an evaluation of the most affected functions.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Observational
- Topological turning points across the human lifespan.Nature communications · 2025Article
- The Neurobiology of Life Course Socioeconomic Conditions and Associated Cognitive Performance in Middle to Late Adulthood.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Childhood and Life-Course Socioeconomic Position and Cognitive Function in the Adult Population of the Hispanic Community Health Study/Study of Latinos.American journal of epidemiology · 2023Article
- Early adversity changes the economic conditions of mouse structural brain network organization.Developmental psychobiology · 2023Article
- Maternal mental health mediates links between socioeconomic status and child development.Current psychology (New Brunswick, N.J.) · 2023Article
- Pubertal timing and functional neurodevelopmental alterations independently mediate the effect of family conflict on adolescent psychopathology.Developmental cognitive neuroscience · 2021Article
- Development of white matter microstructure and executive functions during childhood and adolescence: a review of diffusion MRI studies.Developmental cognitive neuroscience · 2021Review
- A generative network model of neurodevelopmental diversity in structural brain organization.Nature communications · 2021Observational
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Authors and funding
6 authors.
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Abstract
Previous studies have identified localized associations between childhood environment - namely their socio-economic status (SES) - and particular neural structures. The primary aim of the current study was to test whether associations between SES and brain structure are widespread or limited to specific neural pathways. We employed advances in whole-brain structural connectomics to address this. Diffusion tensor imaging was used to construct whole-brain connectomes in 113 6-12 year olds. We then applied an adapted multi-block partial-least squares (PLS) regression to explore how connectome organisation is associated with childhood SES (parental income, education levels, and neighbourhood deprivation). The Fractional Anisotropy (FA) connectome was significantly associated with childhood SES and this effect was widespread. We then pursued a secondary aim, and demonstrated that the connectome mediated the relationship between SES and cognitive ability (matrix reasoning and vocabulary). However, the connectome did not significantly mediate SES relationships with academic ability (maths and reading) or internalising and externalising behavior. This multivariate approach is important for advancing our theoretical understanding of how brain development may be shaped by childhood environment, and the role that it plays in predicting key outcomes. We also discuss the limitations with this new methodological approach.
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