Evidence map›Paper›PMID 33453303›Full record

ArticleInternational journal of psychophysiology : official journal of the International Organization of Psychophysiology2021

Sources of the frontocentral mismatch negativity and P3a responses in schizophrenia patients and healthy comparison subjects.

Daisuke Koshiyama, Makoto Miyakoshi, Yash B Joshi, Masaki Nakanishi, Kumiko Tanaka-Koshiyama, Joyce Sprock, Gregory A Light

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of psychophysiology : official journal of the International Organization of Psychophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 12 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Daisuke KoshiyamaDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Makoto MiyakoshiSwartz Center for Neural Computation, University of California San Diego, La Jolla, CA, USA. Electronic address: mmiyakoshi@ucsd.edu.
Yash B JoshiDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA; VISN-22 Mental Illness, Research, Education and Clinical Center (MIRECC), VA San Diego Healthcare System, San Diego, CA, USA.
Masaki NakanishiSwartz Center for Neural Computation, University of California San Diego, La Jolla, CA, USA.
Kumiko Tanaka-KoshiyamaDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Joyce SprockDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA; VISN-22 Mental Illness, Research, Education and Clinical Center (MIRECC), VA San Diego Healthcare System, San Diego, CA, USA.
Gregory A LightDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA; VISN-22 Mental Illness, Research, Education and Clinical Center (MIRECC), VA San Diego Healthcare System, San Diego, CA, USA.
University of California, San Diego · USVA San Diego Healthcare System · USMental Illness Research, Education and Clinical Centers · US

Funding

SENSORY GATING &HABITUATION IN SCHIZOPHRENIAR01MH042228 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRAFF, DAVID L. · 1987 to 2015
$6.5M
Pathway(s) From Genes to Functional Deficits of Schizophrenia PatientsR01MH079777 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LIGHT, GREGORY A · 2007 to 2010
$1.4M
SENSORY GATING AND HABITUATION IN SCHIZOPHRENIAR37MH042228 · NIMH · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI BRAFF, DAVID L. · 1993 to 2002
$1.3M
NIMH NIH HHS R01 MH042228NIMH NIH HHS R01 MH079777NIMH NIH HHS R37 MH042228
6 · The paper itself

Abstract

backgroundMismatch negativity (MMN) and P3a are event-related potential measures of early auditory information processing that are increasingly used as translational biomarkers in the development of treatments for neuropsychiatric disorders. These responses are reduced in schizophrenia patients over the frontocentral scalp electrodes and are associated with important domains of cognitive and psychosocial functioning. While MMN and P3a responses are generated by a dynamic network of cortical sources distributed across the temporal and frontal brain regions, it is not clear how these sources independently contribute to MMN and P3a at the primary frontocentral scalp electrode or to abnormalities observed in schizophrenia. This study aimed to determine the independent source contributions and characterize the magnitude of impairment in source-level MMN and P3a responses in schizophrenia patients.

methodsA novel method was applied to back-project the contributions of 11 independent cortical source components to Fz, the primary scalp sensor that is used in clinical studies, in n = 589 schizophrenia patients and n = 449 healthy comparison subjects.

resultsThe groups showed comparable individual source contributions underlying both MMN and P3a responses at Fz. Source-level responses revealed an increasing magnitude of impairment in schizophrenia patients from the temporal to more frontal sources.

conclusionsSchizophrenia patients have a normal architecture of source contributions that are accompanied by widespread abnormalities in source resolved mismatch and P3a responses, with more prominent deficits detected from the frontal sources. Quantification of source contributions and source-level responses accelerates clarification of the neural networks underlying MMN reduction at Fz in schizophrenia patients.

Indexed as

SchizophreniaBrainElectroencephalographyEvoked PotentialsEvoked Potentials, AuditoryFrontal LobeHumansIndependent component analysisMismatch negativityP3aSchizophreniaSource-level analysisTranslational biomarker

Identifiers

PMID33453303
PMCPMC8099045
OpenAlexW3119550534

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.