Evidence map›Paper›PMID 33453281›Full record

ArticleThe Journal of biological chemistry

Optogenetic control of small GTPases reveals RhoA mediates intracellular calcium signaling.

Hironori Inaba, Qianqian Miao, Takao Nakata

Open access · goldAbstract read
In one paragraph

Article in The Journal of biological chemistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Nanobody-based analysis of RhoGTPase stress response inBiotechnology reports (Amsterdam, Netherlands) · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Local RhoA activation induces septin recruitment.bioRxiv : the preprint server for biology · 2025
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Shining a light on RhoA: Optical control of cell contractility.The international journal of biochemistry & cell biology · 2023
    Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Hironori InabaDepartment of Cell Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan; The Center for Brain Integration Research (CBIR), Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
Qianqian MiaoDepartment of Cell Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan; The Center for Brain Integration Research (CBIR), Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
Takao NakataDepartment of Cell Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan; The Center for Brain Integration Research (CBIR), Tokyo Medical and Dental University (TMDU), Tokyo, Japan. Electronic address: info.cbio@tmd.ac.jp.
Tokyo Medical and Dental University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rho/Ras family small GTPases are known to regulate numerous cellular processes, including cytoskeletal reorganization, cell proliferation, and cell differentiation. These processes are also controlled by Ca

Indexed as

AnimalsBiosensing TechniquesCalciumCalcium Signalingcdc42 GTP-Binding ProteinCell DifferentiationCell ProliferationDogsGene Expression RegulationHEK293 CellsHeLa CellsHumansLightLight Signal TransductionMadin Darby Canine Kidney CellsOptogeneticsCalciumcdc42 GTP-Binding ProteinCDC42 protein, humanPhosphoinositide Phospholipase Cphospholipase C epsilonrac1 GTP-Binding ProteinRAC1 protein, humanral GTP-Binding Proteinsrap GTP-Binding Proteinsras ProteinsrhoA GTP-Binding ProteinRHOA protein, humancalciuminositol 1,4,5-triphosphate (IP3)NFAT transcription factoroptogeneticsphospholipase CRas proteinRho (Rho GTPase)signal transduction

Identifiers

PMID33453281
PMCPMC7949103
OpenAlexW3120299016

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.