ArticleMolecular cell2021
Biochemical evidence accumulates across neurons to drive a network-level eruption.
Article in Molecular cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Decay chemicals activate a pH-sensing pathway to initiate a persistent state.bioRxiv : the preprint server for biology · 2026Article
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- Deconstructing a behavioral state: parallel neural integrators control distinct features of an aversive behavioral state inbioRxiv : the preprint server for biology · 2026Article
- Behavioral devaluation by local resistance to dopamine.Nature neuroscience · 2025Article
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- Transient cAMP production drives rapid and sustained spiking in brainstem parabrachial neurons to suppress feeding.Neuron · 2024Article
- Real-Time cAMP Dynamics in Live Cells Using the Fluorescent cAMP Difference Detector In Situ.Journal of visualized experiments : JoVE · 2024Article
- A Cre-dependent reporter mouse for quantitative real-time imaging of protein kinase A activity dynamics.Scientific reports · 2024Article
- A Cre-dependent reporter mouse for quantitative real-time imaging of Protein Kinase A activity dynamics.bioRxiv : the preprint server for biology · 2023Article
- Persistent modulatory actions and task switching in the feeding network of Aplysia.Current opinion in neurobiology · 2023Review
- Competition between stochastic neuropeptide signals calibrates the rate of satiation.Research square · 2023Article
- The emergence and influence of internal states.Neuron · 2022Review
- Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through the cAMP/PKA pathway.Cell reports · 2022Article
- PACmn for improved optogenetic control of intracellular cAMP.BMC biology · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Neural network computations are usually assumed to emerge from patterns of fast electrical activity. Challenging this view, we show that a male fly's decision to persist in mating hinges on a biochemical computation that enables processing over minutes to hours. Each neuron in a recurrent network contains slightly different internal molecular estimates of mating progress. Protein kinase A (PKA) activity contrasts this internal measurement with input from the other neurons to represent accumulated evidence that the goal of the network has been achieved. When consensus is reached, PKA pushes the network toward a large-scale and synchronized burst of calcium influx that we call an eruption. Eruptions transform continuous deliberation within the network into an all-or-nothing output, after which the male will no longer sacrifice his life to continue mating. Here, biochemical activity, invisible to most large-scale recording techniques, is the key computational currency directing behavior and motivational state.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.