ArticleJournal of neuro-oncology2021
Local control and patterns of failure for "Radioresistant" spinal metastases following stereotactic body radiotherapy compared to a "Radiosensitive" reference.
Article in Journal of neuro-oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Percutaneous cryoablation in the management of spinal metastases: a comprehensive systematic review and meta-analysis.Journal of neuro-oncology · 2025Pooled it
- Stereotactic body radiation therapy in elderly patients with spinal metastases.Journal of neuro-oncology · 2026Article
- The transformative role of SBRT in the management of spinal metastases.Nature reviews. Clinical oncology · 2026Review
- Does Duration of Symptoms in Metastatic Spine Disease Affect Recovery and Outcomes? A Systematic Review and Meta-Analysis.Global spine journal · 2026Review
- Clinical outcomes of stereotactic body radiotherapy for spinal metastases with paraspinal extension.Journal of neuro-oncology · 2026Article
- Clinical Outcomes and Prognostic Factors of Stereotactic Radiotherapy for Spinal Metastases With Epidural Spinal Cord Compression Grades 1-2.Cancer medicine · 2026Article
- [Vertebral body metastases : From the clarification of back pain to the treatment decision].Unfallchirurgie (Heidelberg, Germany) · 2026Review
- Overview of Molecular Prognostication for Common Solid Tumor Histologies - What the Surgeon Should Know.Global spine journal · 2025Article
- Advanced Radiotherapy Technologies in Spine Tumors: What the Surgeon Needs to Know.Global spine journal · 2025Article
- Frequency of and risk factors associated with local recurrence after spinal stereotactic body radiation therapy without surgery.Journal of neuro-oncology · 2024Article
- Stereotactic body radiation therapy for spinal metastases: A new standard of care.Neuro-oncology · 2024Review
- Multi-institutional experience of MR-guided stereotactic body radiation therapy for adrenal gland metastases.Clinical and translational radiation oncology · 2024Article
- MRI feature-based radiomics models to predict treatment outcome after stereotactic body radiotherapy for spinal metastases.Insights into imaging · 2023Article
- Stereotactic Body Radiation Therapy for Spine Metastases-Findings from an Australian Population-Based Study.Current oncology (Toronto, Ont.) · 2023Article
- Risk-adapted stereotactic body radiotherapy for patients with cervical spinal metastases.Cancer science · 2022Article
- Radiation myelopathy following stereotactic body radiation therapy for spine metastases.Journal of neuro-oncology · 2022Review
- Percutaneous image-guided cryoablation of spinal metastases: over 10-year experience in two academic centers.European radiology · 2022Article
- Increased Radiosensitivity of Solid Tumors Harboring ATM and BRCA1/2 Mutations.Cancer research and treatment · 2022Article
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe concept of a radioresistant (RR) phenotype has been challenged with use of stereotactic body radiotherapy (SBRT). We compared outcomes following SBRT to RR spinal metastases to a radiosensitive cohort.
methodsRenal cell, melanoma, sarcoma, gastro-intestinal, and thyroid spinal metastases were identified as RR and prostate cancer (PCA) as radiosensitive. The primary endpoint was MRI-based local failure (LF). Secondary endpoints included overall survival (OS) and vertebral compression fracture (VCF).
resultsFrom a prospectively maintained database of 1394 spinal segments in 605 patients treated with spine SBRT, 173 patients/395 RR spinal segments were compared to 94 patients/185 PCA segments. Most received 24-28 Gy in 2 fractions (68.9%) and median follow-up was 15.5 months (range, 1.4-84.2 months). 1- and 2-year LF rates were 19.2% and 22.4% for RR metastases, respectively, which were significantly greater (p < 0.001) than PCA (3.2% and 8.4%, respectively). Epidural disease (HR: 2.47, 95% CI 1.65-3.71, p < 0.001) and RR histology (HR: 2.41, 95% CI 1.45-3.99, p < 0.001) predicted for greater LF. Median OS was 17.4 and 61.0 months for RR and PCA cohorts, respectively. Lung/liver metastases, polymetastatic disease and epidural disease predicted for worse OS. 2-year VCF rates were ~ 13% in both cohorts. Coverage of the CTV V90 (clinical target volume receiving 90% of prescription dose) by ≥ 87% (HR: 2.32, 95% CI 1.29-4.18, p = 0.005), no prior spine radiotherapy (HR: 1.96, 95% CI 1.09-3.55, p = 0.025), and a greater Spinal Instability Neoplasia Score (p = 0.013) predicted for VCF.
conclusionsHigher rates of LF were observed after spine SBRT in RR metastases. Optimization strategies include dose escalation and aggressive management of epidural disease.
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