Evidence map›Paper›PMID 33452973›Full record

ArticleBulletin of experimental biology and medicine2021

Analysis of Cytokines and ATP in Plucked Hair Follicles.

E V Mikhalchik, O V Morozova, T V Tsimbalenko, Z F Kharaeva, N G Balabushevich, V A Lipatova, A G Gadzhigoroeva

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

E V MikhalchikFederal Research Clinical Center of Physical-Chemical Medicine, Federal Medical-Biological Agency of Russia, Moscow, Russia. lemik2007@yandex.ru.
O V MorozovaFederal Research Clinical Center of Physical-Chemical Medicine, Federal Medical-Biological Agency of Russia, Moscow, Russia.
T V TsimbalenkoMoscow Practical Center of Dermatovenerology and Cosmetology, Moscow Healthcare Department, Moscow, Russia.
Z F KharaevaH. M. Berbekov Kabardino-Balkarian State University, Nalchik, Kabardino-Balkarian Republic, Russia.
N G BalabushevichFaculty of Chemistry, M. V. Lomonosov Moscow State University, Moscow, Russia.
V A LipatovaN. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
A G GadzhigoroevaMoscow Practical Center of Dermatovenerology and Cosmetology, Moscow Healthcare Department, Moscow, Russia.
Federal Medical-Biological Agency · RUState Research Center for Dermatovenereology and Cosmetology · RUKabardino-Balkarian State University · RULomonosov Moscow State University · RUMinistry of Health of the Russian Federation · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The concentrations of ATP, IL-6, and IL-10 were measured in extracts of plucked hair follicles from healthy volunteers (normal values) and patients with androgenetic alopecia and then, ATP, IL-6, and IL-10 content was calculated for each follicle. The resulting values were directly proportional to hair follicle length, except for IL-6. The concentration of extracted ATP correlated with lactate dehydrogenase activity indicating cell damage. In patients with androgenetic alopecia, IL-10 content exceeded the normal values in follicles with a length <1 mm and ATP content surpassed the normal in follicles >2 mm long. The content of IL-6 and IL-10 measured by ELISA was comparable with results of mRNA expression assayed by RT-PCR, which attested to moderate level of gene expression. The content of ATP and IL- 10, but not IL-6 depended on the length of plucked hair follicle and on pathogenetic factors affecting hair growth.

Indexed as

Adenosine TriphosphateAnimalsCytokinesEnzyme-Linked Immunosorbent AssayFemaleHair FollicleInterleukin-10Interleukin-6MaleRatsRats, WistarAdenosine TriphosphateCytokinesInterleukin-10Interleukin-6ATPinterleukin-10interleukin-6morphometryplucked hair follicles

Identifiers

PMID33452973
OpenAlexW3121922912

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.