Evidence map›Paper›PMID 33452967›Full record

ArticleInflammopharmacology2021

Miconia albicans and Curcuma longa herbal medicines positively modulate joint pain, function and inflammation in patients with osteoarthritis: a clinical study.

Thiago P O Gomes, Jonathan I N Souza, Lucas C Somerlate, Vanessa A Mendonça, Nerilson M Lima, Gabriela P Carli, Sandra B R Castro, Teresinha de Jesus A S Andrade, João V L Dias, Marcone A L Oliveira and 2 more

Registry-linked trialAbstract readComparative StudyControlled Clinical Trial
PubMed Publisher
In one paragraph

Article in Inflammopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06105840 (Effect of Combination of Curcuminoid Standardized Turmeric Extract With Acupressure on Inflammatory Markers, Endorphins and Quality of Life in Elderly People With Osteoarthritis Genu), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06105840 phase1 / phase2unknown statusnot on this mapstarted 2023, after this paper: background citation

Effect of Combination of Curcuminoid Standardized Turmeric Extract With Acupressure on Inflammatory Markers, Endorphins and Quality of Life in Elderly People With Osteoarthritis Genu

TypeinterventionalSponsorGadjah Mada UniversityRan2023 to 2023Enrolled70ConditionsOsteoarthritis, KneeArmsAcupressure and Standardized Curcuminoid from Turmeric Extract, Sham Acupressure and Placebo
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Efficacy ofJournal of rheumatic diseases · 2025
    Article
  4. Review
  5. Review
  6. Review
  7. The GenusMolecules (Basel, Switzerland) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Thiago P O GomesFaculdade de Medicina Do Mucuri, Universidade Federal Dos Vales Do Jequitinhonha E Mucuri, Teófilo Otoni, MG, Brasil.
Jonathan I N SouzaFaculdade de Medicina Do Mucuri, Universidade Federal Dos Vales Do Jequitinhonha E Mucuri, Teófilo Otoni, MG, Brasil.
Lucas C SomerlateFaculdade de Medicina Do Mucuri, Universidade Federal Dos Vales Do Jequitinhonha E Mucuri, Teófilo Otoni, MG, Brasil.
Vanessa A MendonçaDepartamento de Fisioterapia, Universidade Federal Dos Vales Do Jequitinhonha E Mucuri, Diamantina, MG, Brasil.
Nerilson M LimaUniversidade Federal de Juiz de Fora, Juiz de Fora, MG, Brasil.
Gabriela P CarliUniversidade Federal de Juiz de Fora, Juiz de Fora, MG, Brasil.
Sandra B R CastroDepartamento de Farmácia, Universidade Federal de Juiz de Fora, Governador Valadares, MG, Brasil.
Teresinha de Jesus A S AndradeNúcleo de Pesquisa Aplicada Às Ciências, Instituto Federal Do Maranhão, Maranhão, Brasil.
João V L DiasFaculdade de Medicina Do Mucuri, Universidade Federal Dos Vales Do Jequitinhonha E Mucuri, Teófilo Otoni, MG, Brasil.
Marcone A L OliveiraUniversidade Federal de Juiz de Fora, Juiz de Fora, MG, Brasil.
Caio C S AlvesFaculdade de Medicina Do Mucuri, Universidade Federal Dos Vales Do Jequitinhonha E Mucuri, Teófilo Otoni, MG, Brasil.
Alessandra P CarliInstituto de Ciências, Engenharia E Tecnologia, Universidade Federal Dos Vales Do Jequitinhonha E Mucuri, Teófilo Otoni, MG, Brasil. alessandrapcarli@hotmail.com.
Universidade Federal dos Vales do Jequitinhonha e Mucuri · BRUniversidade Federal de Juiz de Fora · BRInstituto Federal do Maranhão · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aims to evaluate the analgesic and modulating effect of Curcuma longa and Miconia albicans herbal medicines in knee's osteoarthritis (OA) treatment. This longitudinal study evaluated 24 patients with OA. The patients were divided into three groups: ibuprofen (1200 mg/day), C. longa (1000 mg/day) and M. albicans (1000 mg/day). The medications were applied orally for 30 days. The synovial fluid of the knee joint was collect at the first (day 0) and the last medical (day 30) consultation. The groups treated with herbal medicines presented the same results when compared to Ibuprofen. The comparison of the means of Total WOMAC for M. albicans before and after treatment presented a statistically significant difference (mean day 0 = 57.19; mean day 30 = 31.02) as well as variation of Total WOMAC for C. longa (mean day 0 = 54.79; mean day 30 = 37.08). The WOMAC Total and the VASP were compared, it was found that there was a significant decrease in the means in the C. longa and M. albicans groups, as well as in the Ibuprofen group after treatment. The study demonstrated that the treatment of knee OA with C. longa or M. albicans positively interferes with patients pain and functionality, decreased WOMAC and VASP scores, leading to functional improvement of these patients. This is the first clinical study demonstrating the analgesic and anti-inflammatory effect on knee osteoarthritis from M. albicans comparable to Ibuprofen drug.

Indexed as

AdultAgedAged, 80 and overAnti-Inflammatory Agents, Non-SteroidalArthralgiaCurcumaFemaleHumansIbuprofenInflammationLongitudinal StudiesMaleMelastomataceaeMiddle AgedOsteoarthritis, KneePlant ExtractsAnti-Inflammatory Agents, Non-SteroidalIbuprofenPlant Extractsturmeric extractCurcuma longaIbuprofenInflammatory mediatorsKnee osteoarthritisMiconia albicansPain measurement

Identifiers

PMID33452967
OpenAlexW3122264504

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.