Evidence map›Paper›PMID 33452942›Full record

ArticleWorld journal of microbiology & biotechnology2021

Genome-scale revealing the central metabolic network of the fast growing methanotroph Methylomonas sp. ZR1.

Wei Guo, Yang Li, Ronglin He, Wuxi Chen, Feng Gao, Demao Li, Xiaoping Liao

Abstract read
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In one paragraph

Article in World journal of microbiology & biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wei GuoTianjin Key Laboratory for Industrial Biological Systems and Bioprocessing Engineering, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Science, Tianjin, 300308, China.ORCID http://orcid.org/0000-0001-9638-1853
Yang LiTianjin Institute of Industrial Biotechnology, Chinese Academy of Science, Tianjin, 300308, China.
Ronglin HeTianjin Key Laboratory for Industrial Biological Systems and Bioprocessing Engineering, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Science, Tianjin, 300308, China.
Wuxi ChenTianjin Key Laboratory for Industrial Biological Systems and Bioprocessing Engineering, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Science, Tianjin, 300308, China.
Feng GaoTianjin Key Laboratory for Industrial Biological Systems and Bioprocessing Engineering, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Science, Tianjin, 300308, China.
Demao LiTianjin Key Laboratory for Industrial Biological Systems and Bioprocessing Engineering, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Science, Tianjin, 300308, China. li_dm@tib.cas.cn.
Xiaoping LiaoTianjin Institute of Industrial Biotechnology, Chinese Academy of Science, Tianjin, 300308, China. liao_xp@tib.cas.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methylomonas sp. ZR1 was an isolated new methanotrophs that could utilize methane and methanol growing fast and synthesizing value added compounds such as lycopene. In this study, the genomic study integrated with the comparative transcriptome analysis were taken to understanding the metabolic characteristic of ZR1 grown on methane and methanol at normal and high temperature regime. Complete Embden-Meyerhof-Parnas pathway (EMP), Entner-Doudoroff pathway (ED), Pentose Phosphate Pathway (PP) and Tricarboxy Acid Cycle (TCA) were found to be operated in ZR1. In addition, the energy saving ppi-dependent EMP enzyme, coupled with the complete and efficient central carbon metabolic network might be responsible for its fast growing nature. Transcript level analysis of the central carbon metabolism indicated that formaldehyde metabolism was a key nod that may be in charge of the carbon conversion efficiency (CCE) divergent of ZR1 grown on methanol and methane. Flexible nitrogen and carotene metabolism pattern were also investigated in ZR1. Nitrogenase genes in ZR1 were found to be highly expressed with methane even in the presence of sufficient nitrate. It appears that, higher lycopene production in ZR1 grown on methane might be attributed to the higher proportion of transcript level of C

Indexed as

Metabolic Networks and PathwaysBacterial ProteinsGene Expression ProfilingGene Expression Regulation, BacterialGenome, BacterialGenome SizeMethaneMethanolMethylomonasMolecular Sequence AnnotationPhylogenySequence Analysis, RNATemperatureWhole Genome SequencingBacterial ProteinsMethaneMethanolGenomeMetabolic networkMethylomonas

Identifiers

PMID33452942

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.