ArticleExperimental & applied acarology2021
A novel defensin-like peptide contributing to antimicrobial and antioxidant capacity of the tick Dermacentor silvarum (Acari: Ixodidae).
Article in Experimental & applied acarology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Leech Diversity in the Maghreb (North Africa): A Checklist and a Case Report of Parasitism on a Berber Toad (Biology · 2026Article
- Characterization of two novel defensins Han-Def1 and Han-Def2 fromFrontiers in microbiology · 2026Article
- Integrated transcriptomic and proteomic analysis of the immune response inFrontiers in immunology · 2025Article
- Antimicrobial peptide 2K4L inhibits the inflammatory response in macrophages and Caenorhabditis elegans and protects against LPS-induced septic shock in mice.Scientific reports · 2024Article
- Integrative analysis highlights molecular and immune responses of tickFrontiers in cellular and infection microbiology · 2023Article
- Defensins as a promising class of tick antimicrobial peptides: a scoping review.Infectious diseases of poverty · 2022Article
- RETRACTED: An Overview of Antimicrobial Stewardship Optimization: The Use of Antibiotics in Humans and Animals to Prevent Resistance.Antibiotics (Basel, Switzerland) · 2022Review
- Characterization of an Arabidopsis Defensin-like Gene Conferring Resistance against Nematodes.Plants (Basel, Switzerland) · 2022Article
- Antimicrobial Peptides: A Potent Alternative to Antibiotics.Antibiotics (Basel, Switzerland) · 2021Review
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Defensins are the most diverse groups of antimicrobial peptides in invertebrate animals. In ticks, defensins show great potential as targets for tick control, and display future prospect for therapeutic drug development. In the present study, a novel defensin-like gene (Ds-defensin) contributing to the antimicrobial and antioxidant capacity of the tick Dermacentor silvarum was characterized. The full-length of the Ds-defensin gene was 382 bp, which displayed tissue-specific expression and was highly abundant in the salivary glands and carcasses of the adults. It encodes a 71-amino acid defensin-like protein, and the protein precursor is characterized by a 22-amino acid signal peptide and a 34-amino acid mature peptide. The peptide displayed potent activity against most of the tested gram-positive bacteria, including Staphylococcus aureus, S. carnosus and Nocardia asteroides, and one tested gram-negative bacterium, Psychrobacter faecalis. Scanning electron microscopy revealed that the cell wall and surface of treated bacteria became rough and gradually formed pores after a 30-min exposure to the Ds-defensin peptide. Additionally, the peptide also showed significant antioxidant capacity. The above results implied that the defensin-like peptide may play an important role in tick defense and the interaction with microorganisms.
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