Evidence map›Paper›PMID 33452913›Full record

ArticleMedical molecular morphology2021

A case of "ETV6-FISH-negative" secretory carcinoma of the parotid gland: immunohistochemical study.

Hiroshi Harada, Koji Irie, Shin-Ichi Nakatsuka, Takakazu Sasaguri, Keiichiro Honma, Akira Kurose

Abstract readCase ReportsLetter
PubMed Publisher
In one paragraph

Article in Medical molecular morphology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Hiroshi HaradaDepartment of Anatomic Pathology, Hirosaki University Graduate School of Medicine, 5 Zaifu, Hirosaki, 036-8562, Japan. harapppiii@kzd.biglobe.ne.jp.
Koji IrieDepartment of Pathology, Fukuoka Tokushukai Hospital, Kasuga, Japan.
Shin-Ichi NakatsukaDepartment of Diagnostic Pathology, Sakai City Medical Center, Sakai, Japan.
Takakazu SasaguriDepartment of Diagnostic Pathology, Kitakyushu General Hospital, Kitakyushu, Japan.
Keiichiro HonmaDepartment of Diagnostic Pathology and Cytology, Osaka International Cancer Institute, Osaka, Japan.
Akira KuroseDepartment of Anatomic Pathology, Hirosaki University Graduate School of Medicine, 5 Zaifu, Hirosaki, 036-8562, Japan.
Hirosaki University · JPFukuoka Tokushukai Hospital · JPOsaka Medical Center for Cancer and Cardiovascular Diseases · JPSakai Municipal Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Secretory carcinoma of the salivary glands is a relatively new disease concept, and is characterized by "morphological resemblance to mammary secretory carcinoma and ETV6-NTRK3 gene fusion." Herein we describe a confusing case and briefly discuss practical diagnostic problems. The patient was a 71-year-old Japanese man who had a tumor consistent with secretory carcinoma at the microscopic and immunohistochemical levels. Immunohistochemically, EMA and S100 protein were noted to be positive along with various cytokeratins as well as mammaglobin and pSTAT5. Moreover, vimentin was focally positive. Smooth muscle actin, p63, p40, and androgen receptor were negative. However, a search using fluorescence in situ hybridization did not reveal a definite split signal for the ETV6 gene. It is presumed that confirming the diagnosis of secretory carcinoma without genetic retrieval will be accepted as a diagnostic method, and we hope that worldwide general recognition may earlier reach "gradual acceptance."

Indexed as

AgedBiomarkers, TumorETS Translocation Variant 6 ProteinGene Expression Regulation, NeoplasticHumansImmunohistochemistryKeratinsMaleMammary Analogue Secretory CarcinomaParotid NeoplasmsProto-Oncogene Proteins c-etsRepressor ProteinsS100 ProteinsSTAT5 Transcription FactorBiomarkers, TumorETS Translocation Variant 6 ProteinKeratinsProto-Oncogene Proteins c-etsRepressor ProteinsS100 ProteinsSTAT5 Transcription FactorETV6 geneFluorescence in situ hybridizationImmunohistochemistrypSTAT5Secretory carcinoma

Identifiers

PMID33452913
OpenAlexW3124359680

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.