ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2021
Genome-wide association analysis reveals seed protein loci as determinants of variations in grain mold resistance in sorghum.
Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 56 citations in OpenAlex.
- Genome-wide association analysis reveals genetic variations and candidate genes associated with tannin and starch contents in sorghum.BMC genomics · 2026Article
- A haplotype-layered GWAS identifies a multi-trait grain mold resistance hub on sorghum chromosome 5.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- SbC1, an R2R3-MYB transcription factor, specifically regulates anthocyanin accumulation in sorghum coleoptiles.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Cold tolerance SNPs and candidate gene mining in the soybean germination stage based on genome-wide association analysis.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Exploring the genetic basis of anthracnose resistance in Ethiopian sorghum through a genome-wide association study.BMC genomics · 2024Article
- Additive and Dominance Genome-Wide Association Studies Reveal the Genetic Basis of Heterosis Related to Growth Traits of Duhua Hybrid Pigs.Animals : an open access journal from MDPI · 2024Article
- High-yield hybrid breeding of Camellia oleifolia based on ISSR molecular markers.BMC plant biology · 2024Article
- The Late Embryogenesis Abundant Proteins in Soybean: Identification, Expression Analysis, and the Roles of GmLEA4_19 in Drought Stress.International journal of molecular sciences · 2023Article
- E-GWAS: an ensemble-like GWAS strategy that provides effective control over false positive rates without decreasing true positives.Genetics, selection, evolution : GSE · 2023Article
- Genome-Wide Association Study of Seed Morphology Traits in Senegalese Sorghum Cultivars.Plants (Basel, Switzerland) · 2023Article
- GWAS of grain color and tannin content in Chinese sorghum based on whole-genome sequencing.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- GWAS of grain color and tannin content in Chinese sorghum based on whole-genome sequencing.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Functional genomic effects of indels using Bayesian genome-phenome wide association studies in sorghum.Frontiers in genetics · 2023Article
- Recent advancements in the breeding of sorghum crop: current status and future strategies for marker-assisted breeding.Frontiers in genetics · 2023Review
- Potential of underutilized crops to introduce the nutritional diversity and achieve zero hunger.Functional & integrative genomics · 2022Article
- OMICS in Fodder Crops: Applications, Challenges, and Prospects.Current issues in molecular biology · 2022Review
- Combined GWAS and Transcriptome Analyses Provide New Insights Into the Response Mechanisms of Sunflower Against Drought Stress.Frontiers in plant science · 2022Article
- Review
- Transcriptome analysis of early stages of sorghum grain mold disease reveals defense regulators and metabolic pathways associated with resistance.BMC genomics · 2021Article
- The Sorghum Grain Mold Disease Complex: Pathogens, Host Responses, and the Bioactive Metabolites at Play.Frontiers in plant science · 2021Review
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
key messageGWAS analysis revealed variations at loci harboring seed storage, late embryogenesis abundant protein, and a tannin biosynthesis gene associated with sorghum grain mold resistance. Grain mold is the most important disease of sorghum [Sorghum bicolor (L.) Moench]. It starts at the early stages of grain development due to concurrent infection by multiple fungal species. The genetic architecture of resistance to grain mold is poorly understood. Using a diverse set of 635 Ethiopian sorghum accessions, we conducted a multi-stage disease rating for resistance to grain mold under natural infestation in the field. Through genome-wide association analyses with 173,666 SNPs and multiple models, two novel loci were identified that were consistently associated with grain mold resistance across environments. Sequence variation at new loci containing sorghum KAFIRIN gene encoding a seed storage protein affecting seed texture and LATE EMBRYOGENESIS ABUNDANT 3 (LEA3) gene encoding a protein that accumulates in seeds, previously implicated in stress tolerance, were significantly associated with grain mold resistance. The KAFIRIN and LEA3 loci were also significant factors in grain mold resistance in accessions with non-pigmented grains. Moreover, we consistently detected the known SNP (S4_62316425) in TAN1 gene, a regulator of tannin accumulation in sorghum grain to be significantly associated with grain mold resistance. Identification of loci associated with new mechanisms of resistance provides fresh insight into genetic control of the trait, while the highly resistant accessions can serve as sources of resistance genes for breeding. Overall, our association data suggest the critical role of loci harboring seed protein genes and implicate grain chemical and physical properties in sorghum grain mold resistance.
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