ArticleBrain and behavior2021
Components determining the slowness of information processing in parkinson's disease.
Article in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Neuropsychological Changes in Isolated REM Sleep Behavior Disorder: A Systematic Review and Meta-analysis of Cross-sectional and Longitudinal Studies.Neuropsychology review · 2024Pooled it
- Stochastic resonance stimulation effect on stability during walking in people with Parkinson disease.International biomechanics · 2025Trial
- Feasibility and Effects of an Immersive Virtual Reality Exergame Program on Physical Functions in Institutionalized Older Adults: A Randomized Clinical Trial.Sensors (Basel, Switzerland) · 2022Trial
- Article
- Misfolded Proteins and Cognitive Decline: Mechanistic Insights into Neurodegenerative Disorders.Neurology international · 2026Review
- Cognitive alterations related to driving performance in Parkinson's disease detected by a driving simulator.Scientific reports · 2025Observational
- Movement-related activity in the internal globus pallidus of the parkinsonian macaque.Journal of neurophysiology · 2025Article
- Virtual Reality Gaming and Its Impact and Effectiveness in Improving Eye-Hand Coordination and Attention Concentration in the Oldest-Old Population.Journal of clinical medicine · 2025Article
- Altered angular gyrus activation during the digit symbol substitution test in people living with HIV: beyond information processing speed deficits.Scientific reports · 2025Article
- Transcutaneous Kilohertz High-Frequency Alternating Current at 10 kHz for Upper-Limb Tremor in People with Parkinson's Disease: A Double-Blind, Randomized, Crossover Study.Journal of clinical medicine · 2024Article
- Online cognitive monitoring technology for people with Parkinson's disease and REM sleep behavioural disorder.NPJ digital medicine · 2024Article
- Bradyphrenia and Tachyphrenia in Idiopathic Parkinsonism Appear, in Part, Iatrogenic: An Observational Study with Systematic Review Background.Journal of clinical medicine · 2023Article
- Immersive Virtual Reality Reaction Time Test and Relationship with the Risk of Falling in Parkinson's Disease.Sensors (Basel, Switzerland) · 2023Article
- Validation of Cognitive Rehabilitation as a Balance Rehabilitation Strategy in Patients with Parkinson's Disease: Study Protocol for a Randomized Controlled Trial.Medicina (Kaunas, Lithuania) · 2021Article
- Components determining the slowness of information processing in parkinson's disease.Brain and behavior · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
introductionBradyphrenia is a key cognitive feature in Parkinson's disease (PD). There is no consensus on whether information processing speed is impaired or not beyond motor performance.
objectiveThis study aims to explore which perceptual, motor, or cognitive components of information processing are involved in the slowdown affecting cognitive performance.
methodsThe study included 48 patients with PD (age: 63, 3 ± 8, 18; HY I-III; UPDRS 15,46 ± 7,76) and 53 healthy controls (age: 60,09 ± 12,83). Five reaction time (RT) tasks were administered to all participants. The average RT in each of the tasks and the percentage of correct answers were measured. Patients with PD were in "ON state" at the time of the evaluation. Perceptual, motor, and cognitive components were isolated by means of a series of ANCOVAs.
resultsAs expected, the motor component was slowed down in patients with PD. Moreover, while patients with PD showed slower RT than controls in all tasks, differences between groups did not exponentially increase with the increasing task complexity. ANCOVA analyses also revealed that the perceptual and sustained alert component resulted to be slowed down, with no differences being found in any of the remaining isolated cognitive components (i.e., response strategy-inhibition, decisional, visual search, or interference control).
conclusionsThe results revealed that slowness of information processing in PD was mainly associated with an impaired processing speed of the motor and perceptual-alertness components analyzed. The results may help designing new neurorehabilitation strategies, focusing on the improvement of perceptual and alertness mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.