Evidence map›Paper›PMID 33452672›Full record

ArticleJournal of cellular physiology2021

Oscillating calcium signals in smooth muscle cells underlie the persistent basal tone of internal anal sphincter.

Ping Lu, Jun Chen, Chenghai Zhang, Dieter Saur, Christina E Baer, Lawrence M Lifshitz, Kevin E Fogarty, Ronghua ZhuGe

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Mode Switch of CaFrontiers in physiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Ping LuDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Jun ChenDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Chenghai ZhangDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute at Harvard Medical School, Boston, Massachusetts, USA.
Dieter SaurDepartment of Internal Medicine II, Klinikum rechts der Isar, Technische Universität München, München, Germany.
Christina E BaerDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Lawrence M LifshitzProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Kevin E FogartyProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Ronghua ZhuGeDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA.ORCID 0000-0002-8953-1494
University of Massachusetts Chan Medical School · USBoston Biomedical Research Institute · USTUM Klinikum · DE

Funding

Function and regulation of elemental Ca2+ signaling in urethral smooth muscleR01DK098586 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ZHUGE, RONGHUA · 2013 to 2013
$167k
NIDDK NIH HHS R01 DK098586NIH HHS RO1DR098586
6 · The paper itself

Abstract

A persistent basal tone in the internal anal sphincter (IAS) is essential for keeping the anal canal closed and fecal continence; its inhibition via the rectoanal inhibitory reflex (RAIR) is required for successful defecation. However, cellular signals underlying the IAS basal tone remain enigmatic. Here we report the origin and molecular mechanisms of calcium signals that control the IAS basal tone, using a combination approach including a novel IAS slice preparation that retains cell arrangement and architecture as in vivo, 2-photon imaging, and cell-specific gene-modified mice. We found that IAS smooth muscle cells generate two forms of contractions (i.e., phasic and sustained contraction) and Ca

Indexed as

Anal CanalAnimalsCalciumCalcium SignalingMiceMuscle ContractionMuscle, SmoothMyocytes, Smooth MuscleNitric OxideReflexCalciumNitric Oxidecalcium oscillationsInternal anal sphincterIon channelsphasic contractionsustained contraction

Identifiers

PMID33452672
PMCPMC8132622
OpenAlexW3124594586

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.