Observational studyAnnals of surgical oncology2021
Prediction of Persistent Pain Severity and Impact 12 Months After Breast Surgery Using Comprehensive Preoperative Assessment of Biopsychosocial Pain Modulators.
Observational study in Annals of surgical oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Patient Phenotypic Features on the Experience and Effectiveness of Regional Anesthesia and Postoperative Pain
Yoga for Persistent Post-Surgical Pain (PPSP)
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of physical activity-based interventions to prevent or reduce chronic post-surgical pain.Pain medicine (Malden, Mass.) · 2026Pooled it
- Paravertebral or Serratus Anterior Plane Block Combined with Interpectoral Blocks versus Paravertebral Block for Mastectomy: A Cluster-randomized Trial of 1,507 Patients.Anesthesiology · 2026Trial
- Influence of psychological factors on the benefit from interpectoral and pectoserratus plane block for recovery after partial mastectomy: a randomized controlled trial.Korean journal of anesthesiology · 2025Trial
- A Randomized Controlled Trial of Intraoperative Ketamine for Acute Postsurgical Pain after Breast Cancer Surgery: The Moderating Effect of Baseline Temporal Summation of Pain.Anesthesiology · 2025Trial
- Symptom Networks in Postsurgical Cancer Pain Across Recovery Stages.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2026Observational
- Early post-operative changes in quality of life and psychological symptoms after breast cancer surgery: the role of perceived pain, upper limb disability, and disease acceptance.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Observational
- Longitudinal Changes in Somatosensory Function and Their Association with Pain Trajectory Groups in a Portuguese Cancer Center Cohort.Biomedicines · 2026Article
- Two-part Statistical Model for Identifying Baseline Predictors of Chronic Postsurgical Pain.Anesthesiology · 2026Article
- Age-related differences in psychological distress and persistent postsurgical pain after surgery for management of non-invasive breast lesions.Breast cancer research and treatment · 2026Article
- Associations Between Childhood Adversity and Pain in Breast Cancer Survivors.Biopsychosocial science and medicine · 2026Article
- Cluster analysis of global research hotspots and thematic evolution in breast cancer and general anesthesia a bibliometric study from 1985 to 2024.Discover oncology · 2026Article
- Longitudinal human transcriptomic and spatial gene profiling at the incisional edge during long surgical procedures.Communications biology · 2025Article
- Patient-reported Outcomes After Routine Treatment of In Situ/Atypical Lesions: The PORTAL Study.Annals of surgical oncology · 2025Article
- Chronic Pain in the Cancer Survivor.Current pain and headache reports · 2025Review
- Review
- Intraoperative Opioid Administration Variation in Cardiac Surgery: Predictable, Yet Not Personalized.Anesthesia and analgesia · 2025Article
- Recognizing pain phenotypes: biopsychosocial sources of variability in the transition to chronic postsurgical pain.Regional anesthesia and pain medicine · 2025Review
- At the Intersection of Pain and Sleep: a Roadmap for Preclinical Pain Research.Frontiers in pain research (Lausanne, Switzerland) · 2025Review
- Persistent Pain After Breast Cancer Treatment, an Underreported Burden for Breast Cancer Survivors.Annals of surgical oncology · 2024Article
- Painstaking Progress: A Call for Comprehensive Research and Consistent Outcome Measures of Postsurgical Pain.Anesthesiology · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
14 authors.
Funding
Abstract
backgroundPersistent post-mastectomy pain (PPMP) is a significant negative outcome occurring after breast surgery, and understanding which individual women are most at risk is essential to targeting of preventive efforts. The biopsychosocial model of pain suggests that factors from many domains may importantly modulate pain processing and predict the progression to pain persistence.
methodsThis prospective longitudinal observational cohort study used detailed and comprehensive psychosocial and psychophysical assessment to characterize individual pain-processing phenotypes in 259 women preoperatively. Pain severity and functional impact then were longitudinally assessed using both validated surgery-specific and general pain questionnaires to survey patients who underwent lumpectomy, mastectomy, or mastectomy with reconstruction in the first postsurgical year. An agnostic, multivariable modeling strategy identified consistent predictors of several pain outcomes at 12 months.
resultsThe preoperative characteristics most consistently associated with PPMP outcomes were preexisting surgical area pain, less education, increased somatization, and baseline sleep disturbance, with axillary dissection emerging as the only consistent surgical variable to predict worse pain. Greater pain catastrophizing, negative affect, younger age, higher body mass index (BMI), and chemotherapy also were independently predictive of pain impact, but not severity. Sensory disturbance in the surgical area was predicted by a slightly different subset of factors, including higher preoperative temporal summation of pain.
conclusionsThis comprehensive approach assessing consistent predictors of pain severity, functional impact, and sensory disturbance may inform personalized prevention of PPMP and also may allow stratification and enrichment in future preventive studies of women at higher risk of this outcome, including pharmacologic and behavioral interventions and regional anesthesia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.