Evidence map›Paper›PMID 33452589›Full record

ArticleParasitology research2021

Investigation of circular RNAs in an ectoparasitic mite Varroa destructor (Acarina: Varroidae) of the honey bee.

Zheguang Lin, Hao Xu, Xiaoling Su, Yalu Ke, Wei Wang, Yujiao Li, Mingliang Zhuang, Heng Chen, Yibing Liu, Kang Wang and 2 more

Abstract read
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In one paragraph

Article in Parasitology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zheguang LinApicultural Research Institute, College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, China.
Hao XuApicultural Research Institute, College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, China.
Xiaoling SuJinhua Academy of Agricultural Sciences, Jinhua, 321017, China.
Yalu KeWuzhong Animal Health Supervision Institute, Suzhou, 215100, China.
Wei WangWuzhong Animal Health Supervision Institute, Suzhou, 215100, China.
Yujiao LiShandong Apiculture Breeding of Improved Varieties and Extension Center, Taian, 271000, China.
Mingliang ZhuangApicultural Science Institute of Jilin Province, Jilin, 132108, China.
Heng ChenApicultural Research Institute, College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, China.
Yibing LiuApicultural Research Institute, College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, China.
Kang WangApicultural Research Institute, College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, China.
Guohong ChenApicultural Research Institute, College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, China.
Ting JiApicultural Research Institute, College of Animal Science and Technology, Yangzhou University, Yangzhou, 225009, China. tji@yzu.edu.cn.ORCID http://orcid.org/0000-0002-9235-1996

Funding

Earmarked Fund for Modern Agro-industry Technology Research System (CN) CARS-45-SYZ6National Natural Science Foundation of China 31902220Postdoctoral Research Foundation of China 2019M651983Science and Technology Support Program of Jiangsu Province BE2018353
6 · The paper itself

Abstract

Circular RNAs (circRNAs) are a large class of non-protein-coding transcripts that are involved in a diverse spectrum of regulatory mechanisms across a broad range of biological processes. To date, however, few studies on circRNAs have investigated their role in the biology of invertebrate parasites. The ectoparasitic mite Varroa destructor is perceived as the principal biotic threat towards global honey bee health. This parasite cannot be sustainably controlled partially due to the lack of knowledge about its basic molecular biology. In this paper, we unveil the circRNA profile of V. destructor for the first time and report the sources, distribution, and features of the identified circRNAs. Exonic, intronic, exon-intron, and intergenic circRNAs were discovered and exon-intron circRNAs were the most abundant within the largest spliced length. Three hundred and eighty-six (8.3%) circRNAs were predicted to possess translational potential. Eleven circRNAs, derived from six parental genes, exhibited strong bonds with miRNAs as sponges, suggesting an efficient post-transcriptional regulation. GO term and KEGG pathway enrichment analyses of the parental genes of the identified circRNAs showed that these non-coding RNAs were mainly engaged in protein processing, signal transduction, and various metabolism processes. To our knowledge, this is the first catalog of a circRNA profile of parasitiformes species, which reveals the prevalence of circRNAs in the parasite and provides biological insights for future genetic studies on this ubiquitous parasitic mite.

Indexed as

AnimalsBeesGene Expression RegulationHost-Parasite InteractionsMicroRNAsRNA, CircularVarroidaeMicroRNAsRNA, CircularCircular RNAEctoparasitic miteHoney beeNon-coding RNAVarroa destructor

Identifiers

PMID33452589

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.