Observational studyDiabetologia2021
BMI and BMI change following incident type 2 diabetes and risk of microvascular and macrovascular complications: the EPIC-Potsdam study.
Observational study in Diabetologia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
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Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Causal insights into major risk factors for diabetic kidney disease: a comprehensive meta-analysis and Mendelian randomization study.Renal failure · 2025Pooled it
- Association of magnitude of weight loss and weight variability with mortality and major cardiovascular events among individuals with type 2 diabetes mellitus: a systematic review and meta-analysis.Cardiovascular diabetology · 2022Pooled it
- Safety and efficacy of switching from dulaglutide to tirzepatide across clinically relevant baseline characteristics in participants with T2D: subgroup analysis of SURPASS-SWITCH.BMJ open diabetes research & care · 2026Trial
- The obesity paradox: Retinopathy, obesity, and circulating risk markers in youth with type 2 diabetes in the TODAY Study.Journal of diabetes and its complications · 2022Trial
- Metabolic Risk Predictors Associated With the Onset of Vascular Complications Among Patients With Type 2 Diabetes in Zambia: A Retrospective Statistical Modeling Study.Health science reports · 2026Article
- Association of the combined triglyceride-glucose and frailty index with chronic kidney disease: evidence from two national cohort studies.Endocrine · 2026Article
- Ibero-American position statement on therapeutic recommendations for the preventive management of cardiovascular complications in latin-American patients with type 2 diabetes mellitus: consensus of the prevention council of the inter-American society of cardiology (SIAC-PREVENT).Diabetology & metabolic syndrome · 2026Review
- Global, regional, and national burden of high body mass index-related type 2 diabetes from 1990 to 2021 and projections for 2040.Journal of family medicine and primary care · 2026Article
- Causal relationship between obesity and diabetic neuropathy: A 2-sample Mendelian randomization study.Medicine · 2026Article
- Estimating the Clinical, Quality-of-Life and Economic Impact of Optimized Management of Type 2 Diabetes Patients in Spain.Journal of clinical medicine · 2026Article
- Effect of body mass index change on the development of diabetes mellitus.Endocrine journal · 2026Article
- [Management of type 2 diabetes mellitus in frail patients from the Perspective of Real-World Clinical Practice].Atencion primaria · 2026Observational
- Exploring predictive factors of physiological, biochemical indicators, and lifestyle for macrovascular complications in type 2 diabetes: a synthesis of machine learning models.Frontiers in endocrinology · 2026Article
- Differences in cardiovascular disease incidence according to changes in obesity status in young diabetic patients.Cardiovascular diabetology. Endocrinology reports · 2025Article
- Heterogeneity in the development of diabetes-related complications: narrative review of the roles of ancestry and geographical determinants.Diabetologia · 2025Review
- Improvement in body mass index category was associated with improved cardiometabolic measures and patient-reported outcomes in adults with type 2 diabetes treated with tirzepatide.Diabetes, obesity & metabolism · 2025Article
- High rate of complications in a real-world cohort of youth with T2D: a multicenter analysis.Journal of diabetes and its complications · 2025Article
- Trace elements and risk of diabetes-related vascular complications: results from the EPIC-Potsdam cohort study.Cardiovascular diabetology · 2025Article
- Association of changes in the type 2 diabetes and MASLD/related SLD status with risk of developing cardiovascular disease.Diabetes, obesity & metabolism · 2025Article
- Association Between Hormone Levels and Retinopathy in Patients With Type 2 Diabetes: A Cross-Sectional Study.Translational vision science & technology · 2025Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisStudies suggest decreased mortality risk among people who are overweight or obese compared with individuals with normal weight in type 2 diabetes (obesity paradox). However, the relationship between body weight or weight change and microvascular vs macrovascular complications of type 2 diabetes remains unresolved. We investigated the association between BMI and BMI change with long-term risk of microvascular and macrovascular complications in type 2 diabetes in a prospective cohort study.
methodsWe studied participants with incident type 2 diabetes from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam cohort, who were free of cancer, cardiovascular disease and microvascular disease at diagnosis (n = 1083). Pre-diagnosis BMI and relative annual change between pre- and post-diagnosis BMI were evaluated in multivariable-adjusted Cox models.
resultsThere were 85 macrovascular (myocardial infarction and stroke) and 347 microvascular events (kidney disease, neuropathy and retinopathy) over a median follow-up of 10.8 years. Median pre-diagnosis BMI was 29.9 kg/m CONCLUSIONS/
interpretationAmong people with incident type 2 diabetes, pre-diagnosis BMI was positively associated with microvascular complications, while a reduced risk was observed with weight loss when compared with stable weight. The relationships with macrovascular disease were less clear.
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