ArticleThe ISME journal2021
Mapping the adaptive landscape of a major agricultural pathogen reveals evolutionary constraints across heterogeneous environments.
Article in The ISME journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 48 citations in OpenAlex.
- Review
- Virulent Parasites Emerge in Hosts With Rising Temperatures.Global change biology · 2026Article
- Genome-host association mapping reveals wheat pathogen genes involved in host specialization.Nature plants · 2026Article
- A new method to measure ECPest management science · 2026Article
- Multi-omics analyses reveal the virulence differentiation underlying natural variation inApplied and environmental microbiology · 2025Article
- Recombination and transposition drive genomic structural variation potentially impacting life history traits in a host-generalist fungal plant pathogen.BMC biology · 2025Article
- Copy number variation introduced by a massive mobile element facilitates global thermal adaptation in a fungal wheat pathogen.Nature communications · 2024Article
- Dimensions of genome dynamics in fungal pathogens: from fundamentals to applications.BMC biology · 2024Article
- Effects of plant tissue permeability on invasion and population bottlenecks of a phytopathogen.Nature communications · 2024Article
- Koninginins X-Z, Three New Polyketides fromMolecules (Basel, Switzerland) · 2023Article
- Genome-wide expression QTL mapping reveals the highly dynamic regulatory landscape of a major wheat pathogen.BMC biology · 2023Article
- Combined reference-free and multi-reference based GWAS uncover cryptic variation underlying rapid adaptation in a fungal plant pathogen.PLoS pathogens · 2023Article
- Infectivity and stress tolerance traits affect community assembly of plant pathogenic fungi.Frontiers in microbiology · 2023Article
- Combining High-Resolution Imaging, Deep Learning, and Dynamic Modeling to Separate Disease and Senescence in Wheat Canopies.Plant phenomics (Washington, D.C.) · 2023Article
- Genome-wide association mapping reveals genes underlying population-level metabolome diversity in a fungal crop pathogen.BMC biology · 2022Article
- The influence of genetic architecture on responses to selection under drought in rice.Evolutionary applications · 2022Article
- How large and diverse are field populations of fungal plant pathogens? The case ofEvolutionary applications · 2022Article
- Resolving the Rules of Robustness and Resilience in Biology Across Scales.Integrative and comparative biology · 2022Article
- Genetic differentiation ofMicrobial genomics · 2021Article
- Population-level deep sequencing reveals the interplay of clonal and sexual reproduction in the fungal wheat pathogenMicrobial genomics · 2021Article
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Authors and funding
5 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The adaptive potential of pathogens in novel or heterogeneous environments underpins the risk of disease epidemics. Antagonistic pleiotropy or differential resource allocation among life-history traits can constrain pathogen adaptation. However, we lack understanding of how the genetic architecture of individual traits can generate trade-offs. Here, we report a large-scale study based on 145 global strains of the fungal wheat pathogen Zymoseptoria tritici from four continents. We measured 50 life-history traits, including virulence and reproduction on 12 different wheat hosts and growth responses to several abiotic stressors. To elucidate the genetic basis of adaptation, we used genome-wide association mapping coupled with genetic correlation analyses. We show that most traits are governed by polygenic architectures and are highly heritable suggesting that adaptation proceeds mainly through allele frequency shifts at many loci. We identified negative genetic correlations among traits related to host colonization and survival in stressful environments. Such genetic constraints indicate that pleiotropic effects could limit the pathogen's ability to cause host damage. In contrast, adaptation to abiotic stress factors was likely facilitated by synergistic pleiotropy. Our study illustrates how comprehensive mapping of life-history trait architectures across diverse environments allows to predict evolutionary trajectories of pathogens confronted with environmental perturbations.
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