Evidence map›Paper›PMID 33452434›Full record

Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2021

Efficacy and safety of transcranial direct current stimulation as an add-on treatment for obsessive-compulsive disorder: a randomized, sham-controlled trial.

Renata de Melo Felipe da Silva, Andre R Brunoni, Stephan Goerigk, Marcelo Camargo Batistuzzo, Daniel Lucas da Conceição Costa, Juliana Belo Diniz, Frank Padberg, Giordano D'Urso, Eurípedes Constantino Miguel, Roseli Gedanke Shavitt

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05388539 (TBS Treatment for Treatment-Resistant Depression), which is not on this map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05388539 nacompletednot on this mapstarted 2022, after this paper: background citation

TBS Treatment for Treatment-Resistant Depression: a Randomized, Sham-Controlled Trial

TypeinterventionalSponsorUniversity of Sao PauloRan2022 to 2024Enrolled100ConditionsMajor Depressive Disorder, Unipolar DepressionArmsTheta Burst Stimulation, Sham Stimulation
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 66 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Renata de Melo Felipe da SilvaObsessive-Compulsive Spectrum Disorders Program, Laboratory of Psychopathology and Psychiatric Treatment (LIM-23), Department and Institute of Psychiatry, Hospital das Clínicas, University of São Paulo School of Medicine, Ovidio Pires de Campos, 785/3, São Paulo, 05403-000, Brazil. renatamelof@gmail.com.ORCID http://orcid.org/0000-0002-6212-5568
Andre R BrunoniDepartment of Interdisciplinary Neuromodulation, Laboratory of Neurosciences, National Institute of Biomarkers in Psychiatry, University of São Paulo School of Medicine, Ovidio Pires de Campos, 785/3, São Paulo, 05403-000, Brazil.ORCID http://orcid.org/0000-0002-6310-3571
Stephan GoerigkDepartment of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany.ORCID http://orcid.org/0000-0002-3021-0346
Marcelo Camargo BatistuzzoObsessive-Compulsive Spectrum Disorders Program, Laboratory of Psychopathology and Psychiatric Treatment (LIM-23), Department and Institute of Psychiatry, Hospital das Clínicas, University of São Paulo School of Medicine, Ovidio Pires de Campos, 785/3, São Paulo, 05403-000, Brazil.ORCID http://orcid.org/0000-0003-1347-8241
Daniel Lucas da Conceição CostaObsessive-Compulsive Spectrum Disorders Program, Laboratory of Psychopathology and Psychiatric Treatment (LIM-23), Department and Institute of Psychiatry, Hospital das Clínicas, University of São Paulo School of Medicine, Ovidio Pires de Campos, 785/3, São Paulo, 05403-000, Brazil.
Juliana Belo DinizObsessive-Compulsive Spectrum Disorders Program, Laboratory of Psychopathology and Psychiatric Treatment (LIM-23), Department and Institute of Psychiatry, Hospital das Clínicas, University of São Paulo School of Medicine, Ovidio Pires de Campos, 785/3, São Paulo, 05403-000, Brazil.
Frank PadbergDepartment of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany.
Giordano D'UrsoUnit of Psychiatry and Psychology, Laboratory of Neuromodulation, Department of Neuroscience, Reproductive Science and Odontostomatology, University of Naples Federico II, Naples, Italy.
Eurípedes Constantino MiguelObsessive-Compulsive Spectrum Disorders Program, Laboratory of Psychopathology and Psychiatric Treatment (LIM-23), Department and Institute of Psychiatry, Hospital das Clínicas, University of São Paulo School of Medicine, Ovidio Pires de Campos, 785/3, São Paulo, 05403-000, Brazil.
Roseli Gedanke ShavittObsessive-Compulsive Spectrum Disorders Program, Laboratory of Psychopathology and Psychiatric Treatment (LIM-23), Department and Institute of Psychiatry, Hospital das Clínicas, University of São Paulo School of Medicine, Ovidio Pires de Campos, 785/3, São Paulo, 05403-000, Brazil.
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRHochschule Fresenius · DELudwig-Maximilians-Universität München · DEUniversidade de São Paulo · BRUniversity of Naples Federico II · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obsessive-compulsive disorder (OCD) is a frequent, disabling disorder with high rates of treatment resistance. Transcranial direct current stimulation (tDCS) is a safe, tolerable noninvasive neuromodulation therapy with scarce evidence for OCD. This double-blind, randomized, and sham-controlled study investigates the efficacy of tDCS as add-on treatment for treatment-resistant OCD (failure to respond to at least one previous pharmacological treatment). On 20 consecutive weekdays (4 weeks), 43 patients with treatment-resistant OCD underwent 30 min active or sham tDCS sessions, followed by a 8 week follow-up. The cathode was positioned over the supplementary motor area (SMA) and the anode over the left deltoid. The primary outcome was the change in baseline Y-BOCS score at week 12. Secondary outcomes were changes in mood and anxiety and the occurrence of adverse events. Response was evaluated considering percent decrease of baseline Y-BOCS scores and the Improvement subscale of the Clinical Global Impression (CGI-I) between baseline and week 12. Patients that received active tDCS achieved a significant reduction of OCD symptoms than sham, with mean (SD) Y-BOCS score changes of 6.68 (5.83) and 2.84 (6.3) points, respectively (Cohen's d: 0.62 (0.06-1.18), p = 0.03). We found no between-group differences in responders (four patients in the active tDCS and one in the sham group). Active tDCS of the SMA was not superior to sham in reducing symptoms of depression or anxiety. Patients in both groups reported mild adverse events. Our results suggest that cathodal tDCS over the SMA is an effective add-on strategy in treatment-resistant OCD.

Indexed as

Motor CortexObsessive-Compulsive DisorderTranscranial Direct Current StimulationDouble-Blind MethodHumansTreatment Outcome

Identifiers

PMID33452434
PMCPMC8115679
OpenAlexW3121959574

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.