ArticleScientific reports2021
Metabolomics-based analysis of miniature flask contents identifies tobacco mixture use among the ancient Maya.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 27 citations in OpenAlex.
- An archaeo-metabolomics approach for identifying cedar tar in archaeological samples: differentiating plant products and production processes.Scientific reports · 2026Article
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- Metabolic profiling reveals first evidence of fumigating drug plant Peganum harmala in Iron Age Arabia.Communications biology · 2025Article
- Traditional Indigenous-Amazonian Therapy Involving Ceremonial Tobacco Drinking as Medicine: A Transdisciplinary Multi-Epistemic Observational Study.Health education & behavior : the official publication of the Society for Public Health Education · 2024Observational
- Utilization of a natural language processing-based approach to determine the composition of artifact residues.BMC bioinformatics · 2024Article
- Metabolomics in archaeological science: A review of their advances and present requirements.Science advances · 2023Review
- Human Archaeological Dentin as Source of Polar and Less Polar Metabolites for Untargeted Metabolomic Research: The Case ofMetabolites · 2023Article
- Direct evidence of the use of multiple drugs in Bronze Age Menorca (Western Mediterranean) from human hair analysis.Scientific reports · 2023Article
- Indigenous-Amazonian Traditional Medicine's Usage of the Tobacco Plant: A Transdisciplinary Ethnopsychological Mixed-Methods Case Study.Plants (Basel, Switzerland) · 2023Article
- The regular pattern of metabolite changes in mushroom Inonotus hispidus in different growth periods and exploration of their indicator compounds.Scientific reports · 2022Article
- Chemical Modification of Biomarkers through Accelerated Degradation: Implications for Ancient Plant Identification in Archaeo-Organic Residues.Molecules (Basel, Switzerland) · 2022Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A particular type of miniature ceramic vessel locally known as "veneneras" is occasionally found during archaeological excavations in the Maya Area. To date, only one study of a collection of such containers successfully identified organic residues through coupled chromatography-mass spectrometry methods. That study identified traces of nicotine likely associated with tobacco. Here we present a more complete picture by analyzing a suite of possible complementary ingredients in tobacco mixtures across a collection of 14 miniature vessels. The collection includes four different vessel forms and allows for the comparison of specimens which had previously formed part of museum exhibitions with recently excavated, untreated containers. Archaeological samples were compared with fresh as well as cured reference materials from two different species of tobacco (Nicotiana tabacum and N. rustica). In addition, we sampled six more plants which are linked to mind-altering practices through Mesoamerican ethnohistoric or ethnographic records. Analyses were conducted using UPLC-MS metabolomics-based analytical techniques, which significantly expand the possible detection of chemical compounds compared to previous biomarker-focused studies. Results include the detection of more than 9000 residual chemical features. We trace, for the first time, the presence of Mexican marigold (Tagetes lucida) in presumptive polydrug mixtures.
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