ArticleScientific reports2021
Weighted gene co-expression network analysis of the salt-responsive transcriptomes reveals novel hub genes in green halophytic microalgae Dunaliella salina.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 53 citations in OpenAlex.
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- Harnessing systems biology approach for characterization of carotenoid biosynthesis pathways in microalgae.Biochemistry and biophysics reports · 2024Review
- SGCP: a spectral self-learning method for clustering genes in co-expression networks.BMC bioinformatics · 2024Article
- Trancriptome data mining in combination with co-expression network analysis identifies the functional modules and critical regulators inBiochemistry and biophysics reports · 2024Article
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- Identification of genes associated with abiotic stress tolerance in sweetpotato using weighted gene co-expression network analysis.Plant direct · 2023Article
- Combined analysis of chromatin accessibility and gene expression profiles provide insight into Fucoxanthin biosynthesis inFrontiers in microbiology · 2023Article
- The RNA landscape ofFrontiers in plant science · 2023Article
- Weighted gene co-expression network analysis revealed the key pathways and hub genes of potassium regulating cotton root adaptation to salt stress.Frontiers in plant science · 2023Article
- Identification of stress-related genes by co-expression network analysis based on the improved turbot genome.Scientific data · 2022Article
- Comprehensive Transcriptome Analysis Uncovers Distinct Expression Patterns Associated with Early Salinity Stress in Annual Ryegrass (International journal of molecular sciences · 2022Article
- Transcriptome analysis reveals the proline metabolic pathway and its potential regulation TF-hub genes in salt-stressed potato.Frontiers in plant science · 2022Article
- The Application of Consensus Weighted Gene Co-expression Network Analysis to Comparative Transcriptome Meta-Datasets of Multiple Sclerosis in Gray and White Matter.Frontiers in neurology · 2022Article
- Transcriptome Analysis Revealed the Molecular Response Mechanism of Non-heading Chinese Cabbage to Iron Deficiency Stress.Frontiers in plant science · 2022Article
- Identification of hub genes related to CD4Frontiers in genetics · 2022Article
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Authors and funding
2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Despite responses to salinity stress in Dunaliella salina, a unicellular halotolerant green alga, being subject to extensive study, but the underlying molecular mechanism remains unknown. Here, Empirical Bayes method was applied to identify the common differentially expressed genes (DEGs) between hypersaline and normal conditions. Then, using weighted gene co-expression network analysis (WGCNA), which takes advantage of a graph theoretical approach, highly correlated genes were clustered as a module. Subsequently, connectivity patterns of the identified modules in two conditions were surveyed to define preserved and non-preserved modules by combining the Zsummary and medianRank measures. Finally, common and specific hub genes in non-preserved modules were determined using Eigengene-based module connectivity or module membership (k
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