Evidence map›Paper›PMID 33452360›Full record

ArticleScientific reports2021

A subset of liver resident natural killer cells is expanded in hepatitis C-infected patients with better liver function.

Erin H Doyle, Costica Aloman, Ahmed El-Shamy, Francis Eng, Adeeb Rahman, Arielle L Klepper, Brandy Haydel, Sander S Florman, M Isabel Fiel, Thomas Schiano and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Erin H DoyleDivision of Liver Diseases, Icahn School of Medicine at Mount Sinai School, 1425 Madison Ave., Icahn 11-23, New York, NY, 10029, USA.
Costica AlomanRush University Medical Center, Chicago, IL, USA.
Ahmed El-ShamyDivision of Liver Diseases, Icahn School of Medicine at Mount Sinai School, 1425 Madison Ave., Icahn 11-23, New York, NY, 10029, USA.
Francis EngDivision of Liver Diseases, Icahn School of Medicine at Mount Sinai School, 1425 Madison Ave., Icahn 11-23, New York, NY, 10029, USA.
Adeeb RahmanHuman Immune Monitoring Core, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Arielle L KlepperDivision of Liver Diseases, Icahn School of Medicine at Mount Sinai School, 1425 Madison Ave., Icahn 11-23, New York, NY, 10029, USA.
Brandy HaydelRecanati Miller Transplantation Institute, The Mount Sinai Hospital, New York, NY, USA.
Sander S FlormanRecanati Miller Transplantation Institute, The Mount Sinai Hospital, New York, NY, USA.
M Isabel FielDepartment of Pathology, The Mount Sinai Hospital, New York, NY, USA.
Thomas SchianoRecanati Miller Transplantation Institute, The Mount Sinai Hospital, New York, NY, USA.
Andrea D BranchDivision of Liver Diseases, Icahn School of Medicine at Mount Sinai School, 1425 Madison Ave., Icahn 11-23, New York, NY, 10029, USA. Andrea.Branch@mssm.edu.
Icahn School of Medicine at Mount Sinai · USMount Sinai Hospital · USRush University Medical Center · US

Funding

TRAINING PROGRAM: MECHANISMS OF VIRUS-HOST INTERACTIONST32AI007647 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI Domenico Tortorella · 2000 to 2026
$11.5M
Targeting mononuclear phagocytes development in alcohol induced liver damage: pathological and immunological pathwaysR01AA024762 · NIAAA · RUSH UNIVERSITY MEDICAL CENTER · PI ALOMAN, COSTICA · 2017 to 2021
$1.7M
NIAAA NIH HHS R01 AA024762NIAID NIH HHS T32 AI007647
6 · The paper itself

Abstract

Viral hepatitis leads to immune-mediated liver injury. The rate of disease progression varies between individuals. We aimed to phenotype immune cells associated with preservation of normal liver function during hepatitis C virus (HCV) infection. Clinical data and specimens were obtained from 19 HCV-infected patients undergoing liver transplantation. Liver and peripheral blood mononuclear cells were isolated and eight subsets of innate immune cells were delineated by multiparameter flow cytometry. Cytokine assays and microarrays were performed. Intrahepatic CD56

Indexed as

AgedDisease ProgressionFemaleFlow CytometryHepacivirusHepatitis CHumansImmunity, InnateImmunophenotypingKiller Cells, NaturalLeukocytes, MononuclearLiverLiver Function TestsMaleMiddle Aged

Identifiers

PMID33452360
PMCPMC7810844
OpenAlexW3119200854

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.