ArticleScientific reports2021
Association between low body mass index and increased 28-day mortality of severe sepsis in Japanese cohorts.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 34 citations in OpenAlex.
- Association of Body Mass Index with 28-Day Mortality in Adult Intensive Care Patients with Sepsis: A Retrospective Observational Study.Sisli Etfal Hastanesi tip bulteni · 2026Article
- High blood pressure-targeted management associated with reduced benefits of higher body mass index in elderly patients with septic shock: a post hoc analysis of a multicenter randomized controlled trial.Annals of intensive care · 2026Article
- The Geriatric Nutritional Risk Index and its association with all-cause mortality in cancer patients with sepsis: a dual-center retrospective cohort study.Frontiers in nutrition · 2026Article
- Comparative Analysis of Sepsis Outcomes Across Body Mass Index Groups: A Retrospective Cohort Study.Journal of clinical medicine · 2025Article
- Are we giving too much weight to lean mass loss?Molecular metabolism · 2025Review
- Evaluating the obesity paradox in patients with sepsis and cancer.International journal of obesity (2005) · 2025Article
- Correlation between body mass index and gender-specific 28-day mortality in patients with sepsis: a retrospective cohort study.Frontiers in medicine · 2024Article
- Prior Evaluation of Nutritional Status and Mortality in Patients with Sepsis in South Korea.Nutrients · 2023Article
- Association of obesity and mortality in sepsis patients: A meta-analysis from observational evidence.Heliyon · 2023Article
- Association of body mass index with mortality of sepsis or septic shock: an updated meta-analysis.Journal of intensive care · 2023Article
- Expert consensus on the monitoring and treatment of sepsis-induced immunosuppression.Military Medical Research · 2022Article
- Mortality risks associated with empirical antibiotic activity in Escherichia coli bacteraemia: an analysis of electronic health records.The Journal of antimicrobial chemotherapy · 2022Article
- Underweight but not overweight is associated with excess mortality in septic ICU patients.Wiener klinische Wochenschrift · 2022Article
- Prognostic factors in mobility disability among elderly patients in the emergency department: A single-center retrospective study.Acute medicine & surgeryArticle
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33 authors at 20 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Current research regarding the association between body mass index (BMI) and altered clinical outcomes of sepsis in Asian populations is insufficient. We investigated the association between BMI and clinical outcomes using two Japanese cohorts of severe sepsis (derivation cohort, Chiba University Hospital, n = 614; validation cohort, multicenter cohort, n = 1561). Participants were categorized into the underweight (BMI < 18.5) and non-underweight (BMI ≥ 18.5) groups. The primary outcome was 28-day mortality. Univariate analysis of the derivation cohort indicated increased 28-day mortality trend in the underweight group compared to the non-underweight group (underweight 24.4% [20/82 cases] vs. non-underweight 16.0% [85/532 cases]; p = 0.060). In the primary analysis, multivariate analysis adjusted for baseline imbalance revealed that patients in the underweight group had a significantly increased 28-day mortality compared to those in the non-underweight group (p = 0.031, adjusted odds ratio [OR] 1.91, 95% confidence interval [CI] 1.06-3.46). In a repeated analysis using a multicenter validation cohort (underweight n = 343, non-underweight n = 1218), patients in the underweight group had a significantly increased 28-day mortality compared to those in the non-underweight group (p = 0.045, OR 1.40, 95% CI 1.00-1.97). In conclusion, patients with a BMI < 18.5 had a significantly increased 28-day mortality compared to those with a BMI ≥ 18.5 in Japanese cohorts with severe sepsis.
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